Prospective Cohort Study with a Decision Analysis Approach for the Management of Non-lactational Mastitis
摘要
Non-lactational mastitis (NLM) is a troublesome disease in young and middle-aged women. There is lack of a decision analysis approach for NLM. A prospective cohort study with a decision analysis protocol was carried out for patients with NLM. The study was carried out at a tertiary care hospital from August 2018 until March 2020. A total of 69 patients were recruited. The unit of study was the affected mammary gland. Nine ladies had bilateral breast disease; hence, 78 breasts were studied. The final diagnosis was acute/chronic mastitis in 49 units and granulomatous mastitis in 29 units (13 units were tubercular and 16 were non-tubercular in etiology). The cure rate was 95.9% for acute/chronic mastitis and 89.6% in the granulomatous mastitis group. Granulomatous mastitis was treated with a combination of antibiotics, antitubercular therapy (ATT), prednisolone, and radical mammary duct excision (RDE). Seventeen units (including acute/chronic mastitis and granulomatous mastitis) underwent RDE with three recurrences. The overall cure rate was 93.5%. The decision analysis approach has accomplished cure in most patients with selective use of ATT and prednisolone in the treatment of granulomatous mastitis.