Clinicopathological Features of 12 Cases of Intraductal Papillary Neoplasm of the Bile Duct: A Case Series

Intraductal papillary neoplasm of the bile duct (IPNB) is rare, and its clinicopathological characteristics are still unclear. We retrospectively analyzed the clinicopathological data of IPNB patients who underwent surgical treatment in the Division of Hepatobiliary and Pancreatic Surgery of Zhejiang Provincial People's Hospital from September 2018 to June 2023 and reviewed the IPNB related literature on PubMed. A total of 12 patients with IPNB were enrolled, including 5 males and 7 females, with a median age of 64 years (range, 39–70 years). Abdominal pain (66.7%), jaundice (16.7%) and fever (16.7%) were the most common signs. 66.7% of the patients had a history of biliary stones. 75.0% of the patients had invasive carcinoma. Bile duct dilatation (83.3%), intraductal mass (58.3%) and bile duct wall thickening (25.0%) were the most common imaging findings. Surgical resection is the main treatment. The cumulative survival rates for 1, 3 and 5 years were 100%, 87.5% and 87.5%, respectively. The cumulative recurrence-free survival rates at 1, 3 and 5 years were 90.9%, 68.2% and 51.1%, respectively. More up-to-date research focusing on IPNB is warranted to help us better understand the diagnosis and treatment of this rare disease.