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<p>Excess reactive oxygen species (ROS) and persistent oxidative stress can cause mucosal damage and epithelial dysfunction, accelerating inflammation and the development of inflammatory bowel diseases (IBD). Thus, ROS-scavenging and anti-inflammatory nanomaterials have emerged as promising strategies for treating IBD. Herein, we developed ROS-scavenging anti-inflammatory tannic acid (TA)-iron ion (Fe<sup>2+</sup>)-quercetin (QCT) (TFQ) nanocomplexes via a coordination-based self-assembly process, and evaluated their therapeutic effects on dextran sulphate sodium (DSS)-induced acute colitis mouse model. The prepared TFQ nanocomplexes exhibited good colloidal and storage stabilities under aqueous condition. In addition, they showed excellent free radical- and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-scavenging activities. Further, the cytocompatible TFQ nanocomplexes inhibited pro-inflammatory cytokines (i.e. IL-6 and IL-1β), achieving remarkable anti-inflammatory effects against lipopolysaccharide (LPS)-treated macrophages and cytoprotective effects against H<sub>2</sub>O<sub>2</sub>-treated macrophages. Moreover, systemically administered TFQ nanocomplexes alleviated disease symptoms, including colon shortening and inflammation, in a DSS-induced acute colitis mouse model. These findings suggested that the ROS-scavenging anti-inflammatory TFQ nanocomplexes are a promising therapeutic approach for IBD therapy.</p>

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In vivo therapeutic effects of reactive oxygen species (ROS)-scavenging nanotherapeutics on dextran sulphate sodium-induced acute colitis model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月31日

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  • Ji Sun Park,
  • Kyeongsoon Park

摘要

Excess reactive oxygen species (ROS) and persistent oxidative stress can cause mucosal damage and epithelial dysfunction, accelerating inflammation and the development of inflammatory bowel diseases (IBD). Thus, ROS-scavenging and anti-inflammatory nanomaterials have emerged as promising strategies for treating IBD. Herein, we developed ROS-scavenging anti-inflammatory tannic acid (TA)-iron ion (Fe2+)-quercetin (QCT) (TFQ) nanocomplexes via a coordination-based self-assembly process, and evaluated their therapeutic effects on dextran sulphate sodium (DSS)-induced acute colitis mouse model. The prepared TFQ nanocomplexes exhibited good colloidal and storage stabilities under aqueous condition. In addition, they showed excellent free radical- and hydrogen peroxide (H2O2)-scavenging activities. Further, the cytocompatible TFQ nanocomplexes inhibited pro-inflammatory cytokines (i.e. IL-6 and IL-1β), achieving remarkable anti-inflammatory effects against lipopolysaccharide (LPS)-treated macrophages and cytoprotective effects against H2O2-treated macrophages. Moreover, systemically administered TFQ nanocomplexes alleviated disease symptoms, including colon shortening and inflammation, in a DSS-induced acute colitis mouse model. These findings suggested that the ROS-scavenging anti-inflammatory TFQ nanocomplexes are a promising therapeutic approach for IBD therapy.