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<p>Female menopause is a disease characterized by the gradual loss of ovarian function that occurs before and after menopause. Female menopausal symptoms include osteoporosis, facial flushing, and dyslipidemia. Oats are known to be rich in protein and lipids, and their hulls are mainly used as feed. In this study, we sought to explore the potential of oat hull extract as a treatment for menopause by analyzing its estrogen-like activity and menopause-related biomarkers in ovariectomized (OVX) animals. We investigated changes in mRNA expression and estrogen activity of several menopause-related genes induced by oat hull extract in vitro using MCF-7 breast cancer cells. Additionally, we used an OVX mouse model to investigate the effects of oat hull extract on menopause in vivo through changes in body weight, tissue morphology, and bone mineral density. Therefore, this study suggests that oat hull extract may be a promising alternative for treating female menopause.</p>

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Improvement of menopausal symptoms by oat hull extracts in ovariectomized animal model

  • 期刊论文

  • 发表日期：

    2025年4月11日

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  • Mi-Ja Lee,
  • Yongjin Lee,
  • Han Gyeol Lee,
  • Holim Jin,
  • Yoon-A. Shin,
  • Seung Yeob Song,
  • Woo Duck Seo,
  • Young-Jin Son

摘要

Female menopause is a disease characterized by the gradual loss of ovarian function that occurs before and after menopause. Female menopausal symptoms include osteoporosis, facial flushing, and dyslipidemia. Oats are known to be rich in protein and lipids, and their hulls are mainly used as feed. In this study, we sought to explore the potential of oat hull extract as a treatment for menopause by analyzing its estrogen-like activity and menopause-related biomarkers in ovariectomized (OVX) animals. We investigated changes in mRNA expression and estrogen activity of several menopause-related genes induced by oat hull extract in vitro using MCF-7 breast cancer cells. Additionally, we used an OVX mouse model to investigate the effects of oat hull extract on menopause in vivo through changes in body weight, tissue morphology, and bone mineral density. Therefore, this study suggests that oat hull extract may be a promising alternative for treating female menopause.