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<p>Small-cell lung cancer represents a&#xa0;highly aggressive neuroendocrine subtype of lung cancer. In distant metastatic or extensive-stage small-cell lung cancer, the primary treatment approach consists of non-curative pharmacological therapy. Unfortunately, the long-term prognosis for patients at this stage remains poor.</p><p>This short review examines standard first- and second-line pharmacological treatment for extensive-stage small-cell lung cancer from a&#xa0;European perspective, followed by a&#xa0;discussion of current investigational therapeutic agents.</p>

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Current and future pharmacological therapies for extensive-stage small-cell lung cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月28日

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  • Johannes Schöche,
  • Ariane Steindl,
  • Thorsten Fuereder,
  • Barbara Kiesewetter

摘要

Small-cell lung cancer represents a highly aggressive neuroendocrine subtype of lung cancer. In distant metastatic or extensive-stage small-cell lung cancer, the primary treatment approach consists of non-curative pharmacological therapy. Unfortunately, the long-term prognosis for patients at this stage remains poor.

This short review examines standard first- and second-line pharmacological treatment for extensive-stage small-cell lung cancer from a European perspective, followed by a discussion of current investigational therapeutic agents.