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Objective <p>To design and evaluate a synergistic wound dressing comprising tranexamic acid microspheres encapsulated within a chitosan hydrogel to control bleeding, defend against any infection, and support tissue regeneration.</p> Significance <p>The Combination of the hemostatic effect of tranexamic acid with the antimicrobial and wound-healing properties of chitosan to address the critical challenges in wound management. This innovative approach offers a dual-action system to control bleeding and prevent infection while promoting tissue regeneration, potentially revolutionising wound care, especially in scenarios involving severe bleeding or infection-prone wounds.</p> Methods <p>Tranexamic acid microspheres were formulated and incorporated into a chitosan hydrogel matrix. The formulation was characterised for drug content, in vitro release behaviour, and wound-healing efficacy.</p> Results <p>The hydrogel formulation achieved a high drug content of 84.58%, ensuring effective drug encapsulation. Sustained drug release was observed with 79.50% of the drug released over 36 hours, beneficial over traditional delivery systems. The chitosan hydrogel provided a moist environment for healing while acting as an antimicrobial barrier to prevent infection.</p> Conclusion <p>Encapsulating tranexamic acid microspheres in a chitosan hydrogel enhances its hemostatic, antimicrobial, and wound-healing properties. This innovative formulation displayed superior stability, prolonged drug release, and improved therapeutic outcomes compared to conventional wound dressings, making it a promising option for managing uncontrolled bleeding and infection-prone wounds.</p> Graphical Abstract <p></p>

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Formulation & Development of Bioactive Tranexamic Acid Microsphere–incorporated Chitosan Hydrogel – A DoE – Based Approach

  • 期刊论文

  • 发表日期：

    2026年4月14日

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  • Debarati Basu,
  • Soma Das,
  • Rajdip Goswami,
  • AnirbanDeep Bose,
  • Bhupendra Prajapati,
  • Biswajit Basu

摘要

Objective

To design and evaluate a synergistic wound dressing comprising tranexamic acid microspheres encapsulated within a chitosan hydrogel to control bleeding, defend against any infection, and support tissue regeneration.

Significance

The Combination of the hemostatic effect of tranexamic acid with the antimicrobial and wound-healing properties of chitosan to address the critical challenges in wound management. This innovative approach offers a dual-action system to control bleeding and prevent infection while promoting tissue regeneration, potentially revolutionising wound care, especially in scenarios involving severe bleeding or infection-prone wounds.

Methods

Tranexamic acid microspheres were formulated and incorporated into a chitosan hydrogel matrix. The formulation was characterised for drug content, in vitro release behaviour, and wound-healing efficacy.

Results

The hydrogel formulation achieved a high drug content of 84.58%, ensuring effective drug encapsulation. Sustained drug release was observed with 79.50% of the drug released over 36 hours, beneficial over traditional delivery systems. The chitosan hydrogel provided a moist environment for healing while acting as an antimicrobial barrier to prevent infection.

Conclusion

Encapsulating tranexamic acid microspheres in a chitosan hydrogel enhances its hemostatic, antimicrobial, and wound-healing properties. This innovative formulation displayed superior stability, prolonged drug release, and improved therapeutic outcomes compared to conventional wound dressings, making it a promising option for managing uncontrolled bleeding and infection-prone wounds.

Graphical Abstract