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Purpose <p>This study aimed to develop electrospun nanofiber mats as a buccal delivery system for palonosetron hydrochloride (Palonosetron HCl), examining the effects of polyvinylpyrrolidone concentration, applied voltage, and collector distance on fiber morphology, disintegration time, and drug release behavior.</p> Methods <p>Nanofiber mats were prepared using polyvinylpyrrolidone concentrations of 10–17% (w/w), voltages of 18–21&#xa0;kV, and syringe-to-collector distances of 13–16&#xa0;cm. The physicochemical characterization included fiber diameter, disintegration time, wettability, drug content, and in vitro dissolution. The viscosity and electrical conductivity of the PVP solutions were not directly measured in this study. Instead, the electrospinning conditions were optimized based on the morphological characteristics of the obtained nanofibers, such as fiber diameter and uniformity.</p> Results <p>The optimized formulation exhibited a fiber diameter of 202.2&#xa0;nm, disintegration time of 1.49&#xa0;s, and wettability of 2.38&#xa0;s under conditions of 10% polyvinylpyrrolidone, 16&#xa0;cm collector distance, and 19.89&#xa0;kV voltage. In vitro dissolution showed 95.6% drug release within the first minute and complete release in under five minutes. Stability tests confirmed the nanofiber mats’ robustness, with no significant changes in drug content or properties under long-term conditions.</p> Conclusion <p>These findings demonstrate the potential of polyvinylpyrrolidone -based nanofiber mats for rapid and efficient buccal delivery of Palonosetron HCl, providing improved bioavailability, patient comfort, and compliance, positioning it as a viable alternative to intravenous antiemetic therapy.</p>

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Electrospun Palonosetron Hydrochloride-Loaded Buccal Films: Formulation, Characterization and Potential For Enhanced Drug Delivery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月4日

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  • Burke Velioglu,
  • Juste Baranauskaite,
  • Ebru Türköz Acar,
  • Cetin Tas

摘要

Purpose

This study aimed to develop electrospun nanofiber mats as a buccal delivery system for palonosetron hydrochloride (Palonosetron HCl), examining the effects of polyvinylpyrrolidone concentration, applied voltage, and collector distance on fiber morphology, disintegration time, and drug release behavior.

Methods

Nanofiber mats were prepared using polyvinylpyrrolidone concentrations of 10–17% (w/w), voltages of 18–21 kV, and syringe-to-collector distances of 13–16 cm. The physicochemical characterization included fiber diameter, disintegration time, wettability, drug content, and in vitro dissolution. The viscosity and electrical conductivity of the PVP solutions were not directly measured in this study. Instead, the electrospinning conditions were optimized based on the morphological characteristics of the obtained nanofibers, such as fiber diameter and uniformity.

Results

The optimized formulation exhibited a fiber diameter of 202.2 nm, disintegration time of 1.49 s, and wettability of 2.38 s under conditions of 10% polyvinylpyrrolidone, 16 cm collector distance, and 19.89 kV voltage. In vitro dissolution showed 95.6% drug release within the first minute and complete release in under five minutes. Stability tests confirmed the nanofiber mats’ robustness, with no significant changes in drug content or properties under long-term conditions.

Conclusion

These findings demonstrate the potential of polyvinylpyrrolidone -based nanofiber mats for rapid and efficient buccal delivery of Palonosetron HCl, providing improved bioavailability, patient comfort, and compliance, positioning it as a viable alternative to intravenous antiemetic therapy.