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<p>Zinc nanoparticles exhibit potent anticancer effects through mechanisms like reactive oxygen species (ROS) generation, apoptosis induction, and cell cycle arrest, showing selective toxicity toward cancer cells over normal ones. Plant-synthesized green variants enhance biocompatibility and efficacy, aligning with sustainable nanomedicine approaches. In this work, we described biogenically supported zinc nanoparticles using leaves from <i>Paeonia decomposita</i>. The generated zinc nanoparticles were effectively stabilized by the leaf of <i>Paeonia decomposita</i>. FE-SEM, FT-IR, UV-Vis, EDX, and XRD were used to physicochemically characterize the as-synthesized zinc nanoparticles/<i>Paeonia decomposita</i>. The anticancer properties of the zinc nanoparticles/<i>Paeonia decomposita</i> may successfully eradicate A2780 ovarian cancer cells using the MTT assay. The antioxidant effectiveness of the zinc nanoparticles/<i>Paeonia decomposita</i> was evaluated using the DPPH method. In cell cycle flow cytometry, the zinc nanoparticles/<i>Paeonia decomposita</i> considerably raised the proportion of the S phase and decreased the G0/G1 and G2/M phases percentages. In the molecular pathway analysis of cells exposed to zinc nanoparticles/<i>Paeonia decomposita</i> showed that the particles suppressed the PI3K/AKT/mTOR pathway in cells while increasing the expression of p53. This implies that the main mechanisms underlying the medical events that the extract induced in human ovarian cancer cells are PI3K/AKT/mTOR and p53. The IC<sub>50</sub> value of zinc nanoparticles/<i>Paeonia decomposita</i> was 19 µg/ml against A2780 ovarian cancer cells. It has been demonstrated that zinc nanoparticles/<i>Paeonia decomposita</i> affect the viability of ovarian cancer cells. The zinc nanoparticles/<i>Paeonia decomposita</i>’ antioxidant activity was noteworthy based on the IC<sub>50</sub> value (32&#xa0;µg/ml). Recent zinc nanoparticles/<i>Paeonia decomposita</i> appear to offer anti-human ovarian cancer potential due to their antioxidant properties.</p>

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Antioxidant and Anti-ovarian Cancer Activities of Zinc Nanoparticles/Paeonia decomposita with Following the PI3K/AKT/mTOR Signaling Pathway

  • 期刊论文

  • 发表日期：

    2026年4月15日

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  • Wenli Gu,
  • Caihong Yang

摘要

Zinc nanoparticles exhibit potent anticancer effects through mechanisms like reactive oxygen species (ROS) generation, apoptosis induction, and cell cycle arrest, showing selective toxicity toward cancer cells over normal ones. Plant-synthesized green variants enhance biocompatibility and efficacy, aligning with sustainable nanomedicine approaches. In this work, we described biogenically supported zinc nanoparticles using leaves from Paeonia decomposita. The generated zinc nanoparticles were effectively stabilized by the leaf of Paeonia decomposita. FE-SEM, FT-IR, UV-Vis, EDX, and XRD were used to physicochemically characterize the as-synthesized zinc nanoparticles/Paeonia decomposita. The anticancer properties of the zinc nanoparticles/Paeonia decomposita may successfully eradicate A2780 ovarian cancer cells using the MTT assay. The antioxidant effectiveness of the zinc nanoparticles/Paeonia decomposita was evaluated using the DPPH method. In cell cycle flow cytometry, the zinc nanoparticles/Paeonia decomposita considerably raised the proportion of the S phase and decreased the G0/G1 and G2/M phases percentages. In the molecular pathway analysis of cells exposed to zinc nanoparticles/Paeonia decomposita showed that the particles suppressed the PI3K/AKT/mTOR pathway in cells while increasing the expression of p53. This implies that the main mechanisms underlying the medical events that the extract induced in human ovarian cancer cells are PI3K/AKT/mTOR and p53. The IC50 value of zinc nanoparticles/Paeonia decomposita was 19 µg/ml against A2780 ovarian cancer cells. It has been demonstrated that zinc nanoparticles/Paeonia decomposita affect the viability of ovarian cancer cells. The zinc nanoparticles/Paeonia decomposita’ antioxidant activity was noteworthy based on the IC50 value (32 µg/ml). Recent zinc nanoparticles/Paeonia decomposita appear to offer anti-human ovarian cancer potential due to their antioxidant properties.