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Background <p>Obesity is a chronic metabolic condition characterized by an increase in adipose tissue mass as a result of a positive energy balance. Anti-obesity medications may be used as a supplement to diet and exercise for obese patients who have been unable to lose weight. These medications, however, are less effective and have negative side effects. In recent years, medicinal plants’ effectiveness and biocompatibility have received a lot of attention. Drug development programs and the verification of plant traditional use are currentlyfocused on Cardiometabolic activities in an attempt to identify the bioactive principles and therapeutic effects of herbal prescriptions. The bark of <i>Holarrhena</i> africana and <i>H. congolensis,</i> as well as the seeds and bark of <i>Holarrhenaantidysenterica,</i> have produced the alkaloid conessine.</p> Objective <p>The current study sought to ascertain the anti-obesity benefits of conessine in Wistar rats that were obese due to a high-fat diet.</p> Method <p>For eight weeks, Wistar rats were fed a prepared high-fat meal and waterto promote obesity. Oral administration of conessine at dosage levels of 20 mg/kg b.w. in group IV and 50 mg/kg b.w in groupV,along with orlistat30 mg/kg body weight as standard in group III, was used to assess the <i>in vivo</i> anti-obesity effects from the fifth to eighth week of the study. </p> Result <p>The 50 mg/kg dose significantly reduced body weight gain, fat buildup, and improved lipid profile, reducing inflammation, demonstrating efficacy comparable to orlistat, whereas 20 mg/kg demonstrated moderate benefits against HFD-induced metabolic changes.</p> Conclusion <p>When administered to HFD-induced Wistar rats, a dose of 50 mg/kg b.w. of conessine showed more effective anti-obesity benefits than a dose of 20 mg /kg b.w.</p> Graphical Abstract <p></p>

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Preclinical Investigation of Conessine for the Management of High-Fat Diet-Induced Obesity in Wistar rats

  • 期刊论文

  • 发表日期：

    2026年3月26日

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  • Anjali Singh,
  • Bhupendra Chauhan,
  • Amarjeet Singh

摘要

Background

Obesity is a chronic metabolic condition characterized by an increase in adipose tissue mass as a result of a positive energy balance. Anti-obesity medications may be used as a supplement to diet and exercise for obese patients who have been unable to lose weight. These medications, however, are less effective and have negative side effects. In recent years, medicinal plants’ effectiveness and biocompatibility have received a lot of attention. Drug development programs and the verification of plant traditional use are currentlyfocused on Cardiometabolic activities in an attempt to identify the bioactive principles and therapeutic effects of herbal prescriptions. The bark of Holarrhena africana and H. congolensis, as well as the seeds and bark of Holarrhenaantidysenterica, have produced the alkaloid conessine.

Objective

The current study sought to ascertain the anti-obesity benefits of conessine in Wistar rats that were obese due to a high-fat diet.

Method

For eight weeks, Wistar rats were fed a prepared high-fat meal and waterto promote obesity. Oral administration of conessine at dosage levels of 20 mg/kg b.w. in group IV and 50 mg/kg b.w in groupV,along with orlistat30 mg/kg body weight as standard in group III, was used to assess the in vivo anti-obesity effects from the fifth to eighth week of the study.

Result

The 50 mg/kg dose significantly reduced body weight gain, fat buildup, and improved lipid profile, reducing inflammation, demonstrating efficacy comparable to orlistat, whereas 20 mg/kg demonstrated moderate benefits against HFD-induced metabolic changes.

Conclusion

When administered to HFD-induced Wistar rats, a dose of 50 mg/kg b.w. of conessine showed more effective anti-obesity benefits than a dose of 20 mg /kg b.w.

Graphical Abstract