Scholarlink

Background <p>Cognitive impairment associated with diabetes involves multiple pathological mechanisms, including impaired insulin signaling, neuroinflammatory processes, mitochondrial dysfunction, and tau-related abnormalities. The present study investigated the neuroprotective potential of phytosterol derived from <i>Sechium edule</i> against streptozotocin (STZ)-induced neurotoxicity in Wistar rats.</p> Methods <p>Rats were randomly assigned to five experimental groups (<i>n</i> = 5 per group). Group I served as the normal control. Group II received STZ (50&#xa0;mg/kg, i.p.) to induce diabetes. Group III received STZ (50&#xa0;mg/kg, i.p.) followed by treatment with glibenclamide (10&#xa0;mg/kg, p.o.). Groups IV and V received STZ (50&#xa0;mg/kg, i.p.) in combination with phytosterol from S. <i>edule</i> at doses of 100 and 200&#xa0;mg/kg (p.o.), respectively. Treatments were administered once daily for 28 days.</p> Results <p>STZ administration in rats resulted in reduced behavioral performance, including decreased locomotion score, exploratory activity, and mounting appearance, as well as reduced time spent in the closed arms in the elevated plus maze (EPM) test. In contrast, STZ-treated rats showed an increased recognition index, increased time spent in the open arms, and elevated serum levels of AChE, TNF-α, IL-1β, and IL-6. However, post-treatment with phytosterol from S. <i>edule</i> (100 and 200&#xa0;mg/kg, p.o.) for 28 days significantly normalized these behavioral and biochemical alterations. Furthermore, phytosterol treatment markedly reduced NF-κB and GFAP immunoreactivity and improved the histoarchitecture of the brain in STZ-challenged rats.</p> Conclusions <p>Our finding indicated that phytosterol of <i>S. edule</i> mitigated the harmful effects of STZ-induced neurotoxicity and cognitive impairment in diabetic Wistar rats.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phytosterol from Sechium edule Fruits Attenuates Diabetes-Induced Cognitive Impairment by Reducing Neuroinflammation and Astroglial Activation

  • 期刊论文

  • 发表日期：

    2026年4月25日

查看全文
  • Yachao Wang,
  • Yuanyuan Fu,
  • Qingmei Wang,
  • Juan Du

摘要

Background

Cognitive impairment associated with diabetes involves multiple pathological mechanisms, including impaired insulin signaling, neuroinflammatory processes, mitochondrial dysfunction, and tau-related abnormalities. The present study investigated the neuroprotective potential of phytosterol derived from Sechium edule against streptozotocin (STZ)-induced neurotoxicity in Wistar rats.

Methods

Rats were randomly assigned to five experimental groups (n = 5 per group). Group I served as the normal control. Group II received STZ (50 mg/kg, i.p.) to induce diabetes. Group III received STZ (50 mg/kg, i.p.) followed by treatment with glibenclamide (10 mg/kg, p.o.). Groups IV and V received STZ (50 mg/kg, i.p.) in combination with phytosterol from S. edule at doses of 100 and 200 mg/kg (p.o.), respectively. Treatments were administered once daily for 28 days.

Results

STZ administration in rats resulted in reduced behavioral performance, including decreased locomotion score, exploratory activity, and mounting appearance, as well as reduced time spent in the closed arms in the elevated plus maze (EPM) test. In contrast, STZ-treated rats showed an increased recognition index, increased time spent in the open arms, and elevated serum levels of AChE, TNF-α, IL-1β, and IL-6. However, post-treatment with phytosterol from S. edule (100 and 200 mg/kg, p.o.) for 28 days significantly normalized these behavioral and biochemical alterations. Furthermore, phytosterol treatment markedly reduced NF-κB and GFAP immunoreactivity and improved the histoarchitecture of the brain in STZ-challenged rats.

Conclusions

Our finding indicated that phytosterol of S. edule mitigated the harmful effects of STZ-induced neurotoxicity and cognitive impairment in diabetic Wistar rats.

Graphical Abstract