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Purpose <p>The goal of this research was to develop a topical glycerosomal gel that would deliver quercetin and resveratrol simultaneously to treat arthritis, overcoming their poor skin permeability and low solubility.</p> Methods <p>Thin-film hydration was used to develop glycerosomes, which were then optimized utilizing a two-level, three-factor complete factorial design. Prior to being included into a Carbopol 940 gel, optimized vesicles were assessed for particle size and entrapment effectiveness (EE). Using models of Freund’s Complete Adjuvant (FCA)-induced arthritis (chronic) and carrageenan-induced paw edema (acute), the effectiveness of the treatment was assessed in Wistar rats.</p> Results <p>The optimized batch (Gs5) had an EE of 92.58 ± 2.8% and a particle size of 168.8 ± 10.1&#xa0;nm. Over the course of eight hours, the resultant gel (Gs5G2) achieved a drug release of around 78% by following zero-order release kinetics. The combo gel considerably outperformed indomethacin gel (32%), inhibiting edema by 72% in acute animals. The combination significantly improved haematological indicators, including haemoglobin and RBC levels with lower WBC counts, and decreased the total arthritic index by 48.9% in the chronic FCA model. Histopathological examination of the treated groups showed recovered joint space and nearly normal joint morphology.</p> Conclusion <p>Quercetin and resveratrol worked together in a glycerosomal carrier to provide a strong, long-acting anti-arthritic remedy. Compared to individual polyphenols or conventional topical NSAIDs, this composition provides better joint protection and anti-inflammatory activity.</p>

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Development and Therapeutic Evaluation of a Dual-loaded Glycerosomal Gel of Quercetin and Resveratrol in an Arthritic Rat Model

  • 期刊论文

  • 发表日期：

    2026年3月19日

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  • Jyotsna Kharbanda,
  • Rupa Mazumder,
  • Anmol Dogra,
  • Neelam Singh,
  • Rakhi Mishra

摘要

Purpose

The goal of this research was to develop a topical glycerosomal gel that would deliver quercetin and resveratrol simultaneously to treat arthritis, overcoming their poor skin permeability and low solubility.

Methods

Thin-film hydration was used to develop glycerosomes, which were then optimized utilizing a two-level, three-factor complete factorial design. Prior to being included into a Carbopol 940 gel, optimized vesicles were assessed for particle size and entrapment effectiveness (EE). Using models of Freund’s Complete Adjuvant (FCA)-induced arthritis (chronic) and carrageenan-induced paw edema (acute), the effectiveness of the treatment was assessed in Wistar rats.

Results

The optimized batch (Gs5) had an EE of 92.58 ± 2.8% and a particle size of 168.8 ± 10.1 nm. Over the course of eight hours, the resultant gel (Gs5G2) achieved a drug release of around 78% by following zero-order release kinetics. The combo gel considerably outperformed indomethacin gel (32%), inhibiting edema by 72% in acute animals. The combination significantly improved haematological indicators, including haemoglobin and RBC levels with lower WBC counts, and decreased the total arthritic index by 48.9% in the chronic FCA model. Histopathological examination of the treated groups showed recovered joint space and nearly normal joint morphology.

Conclusion

Quercetin and resveratrol worked together in a glycerosomal carrier to provide a strong, long-acting anti-arthritic remedy. Compared to individual polyphenols or conventional topical NSAIDs, this composition provides better joint protection and anti-inflammatory activity.