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<p>Taxifolin is a naturally occurring bioflavonoid that has been used as a therapeutic agent for several Inflammatory bowel disorders due to its notable antioxidant and anti-inflammatory properties. However, the role of taxifolin in ethanol-induced gastropathy and gut health remains unclear. Here, we investigated the acute toxicity and gastroprotective effects of taxifolin on ethanol-induced gastric ulcers and depicted its related molecular pathways. Sprague male rats were pretreated with either 10% Tween 20, 30&#xa0;mg/kg lansoprazole, or 30&#xa0;mg/kg and 60&#xa0;mg/kg taxifolin before intragastric ethanol delivery to induce ulcers. The results indicated an increased safety margin of taxifolin in rats ingested with up to 500&#xa0;mg/kg. Our data demonstrated the significant gastroprotective potential of Taxifolin (30 and 60&#xa0;mg/kg) by strengthening gastric defense factors (increasing mucin secretion, up-regulating mucopolysaccharides, and maintaining gastric pH), reducing gastric ulcer area by 74.07% and 77.69%, respectively, compared to ulcer controls. Moreover, taxifolin supplementation ameliorated gastric tissue alterations, denoted by fewer hemorrhagic/lesion areas, less epithelial cell loss, and reduced submucosal edema with leucocytes. Taxifolin pretreatment enhanced the production of antioxidants (glutathione peroxidase, catalase, and superoxide dismutase), as well as lowered lipid peroxidation marker (MDA) and pro-inflammatory mediators (TNF-α and interleukin-6). The anti-apoptotic effects of taxifolin were evidenced by increased HSP 70 and reduced Bax protein levels in gastric tissues. These findings present taxifolin as a potent inhibitor of gastric ulcer, which could be a new natural source for bioformulation.</p>

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Gastroprotective Effects of Taxifolin on Ethanol-Mediated Gastropathy in vivo: Role of Anti-Apoptotic, Antioxidant, and Anti-Inflammatory Mediators

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Khalid M. Alqaisi,
  • Khaled Abdul-aziz Ahmed,
  • Noralhuda Ayad Ibrahim,
  • Hawar Jawdat jaffar,
  • Goran Noori Saleh,
  • Ahmed A.J. Jabbar,
  • Abdulmohsen I. Algefare,
  • Manal A. Alfwuaires,
  • Talal Salem Al-Qaisi,
  • Ahlam Dhafer Alshehri,
  • Hanan Ibrahim Althagbi

摘要

Taxifolin is a naturally occurring bioflavonoid that has been used as a therapeutic agent for several Inflammatory bowel disorders due to its notable antioxidant and anti-inflammatory properties. However, the role of taxifolin in ethanol-induced gastropathy and gut health remains unclear. Here, we investigated the acute toxicity and gastroprotective effects of taxifolin on ethanol-induced gastric ulcers and depicted its related molecular pathways. Sprague male rats were pretreated with either 10% Tween 20, 30 mg/kg lansoprazole, or 30 mg/kg and 60 mg/kg taxifolin before intragastric ethanol delivery to induce ulcers. The results indicated an increased safety margin of taxifolin in rats ingested with up to 500 mg/kg. Our data demonstrated the significant gastroprotective potential of Taxifolin (30 and 60 mg/kg) by strengthening gastric defense factors (increasing mucin secretion, up-regulating mucopolysaccharides, and maintaining gastric pH), reducing gastric ulcer area by 74.07% and 77.69%, respectively, compared to ulcer controls. Moreover, taxifolin supplementation ameliorated gastric tissue alterations, denoted by fewer hemorrhagic/lesion areas, less epithelial cell loss, and reduced submucosal edema with leucocytes. Taxifolin pretreatment enhanced the production of antioxidants (glutathione peroxidase, catalase, and superoxide dismutase), as well as lowered lipid peroxidation marker (MDA) and pro-inflammatory mediators (TNF-α and interleukin-6). The anti-apoptotic effects of taxifolin were evidenced by increased HSP 70 and reduced Bax protein levels in gastric tissues. These findings present taxifolin as a potent inhibitor of gastric ulcer, which could be a new natural source for bioformulation.