Scholarlink

Objective <p>To develop and characterize an econazole nitrate (EN)-loaded cubosomal gel for topical delivery to enhance skin penetration, drug retention, and provide sustained antifungal therapy.</p> Methods <p>Cubosomes were prepared by the top-down method using glyceryl monooleate and Poloxamer 407, then incorporated into a Carbopol 940 gel base. Thirteen formulations were evaluated for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, pH, viscosity, spreadability, and in vitro drug release. Morphology was examined by Transmission Electron Microscopy (TEM), and stability was assessed under ICH conditions.</p> Results <p>The optimized formulation (C5) showed a particle size of 123.5&#xa0;nm, PDI of 0.254, zeta potential of − 34.5 mV, and entrapment efficiency of 90.42%. TEM confirmed spherical morphology with uniform size distribution. The cubosomal gel exhibited a pH of 6.3, viscosity of 34,300 cps, and spreadability of 6.12&#xa0;cm², indicating suitability for topical application. In vitro release studies demonstrated 89.32% cumulative drug release over 12&#xa0;h compared to 56.24% from the pure drug suspension. The formulation remained stable in physical and chemical properties under ICH conditions.</p> Conclusion <p>Econazole-loaded cubosomal gel significantly improved solubility, controlled release, and skin penetration, offering a promising and patient-friendly approach for effective topical antifungal therapy.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Development and Evaluation of Econazole Nitrate Loaded Cubosomal Gel for Enhanced Topical Antifungal Therapy

  • 期刊论文

  • 发表日期：

    2026年2月28日

查看全文
  • Sonam M. Gandhi,
  • Yakub Ismail Bhorat,
  • Devesh U. Kapoor,
  • Samaresh Pal Roy,
  • Omar Awad Alsaidan,
  • Sami I. Alzarea

摘要

Objective

To develop and characterize an econazole nitrate (EN)-loaded cubosomal gel for topical delivery to enhance skin penetration, drug retention, and provide sustained antifungal therapy.

Methods

Cubosomes were prepared by the top-down method using glyceryl monooleate and Poloxamer 407, then incorporated into a Carbopol 940 gel base. Thirteen formulations were evaluated for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, pH, viscosity, spreadability, and in vitro drug release. Morphology was examined by Transmission Electron Microscopy (TEM), and stability was assessed under ICH conditions.

Results

The optimized formulation (C5) showed a particle size of 123.5 nm, PDI of 0.254, zeta potential of − 34.5 mV, and entrapment efficiency of 90.42%. TEM confirmed spherical morphology with uniform size distribution. The cubosomal gel exhibited a pH of 6.3, viscosity of 34,300 cps, and spreadability of 6.12 cm², indicating suitability for topical application. In vitro release studies demonstrated 89.32% cumulative drug release over 12 h compared to 56.24% from the pure drug suspension. The formulation remained stable in physical and chemical properties under ICH conditions.

Conclusion

Econazole-loaded cubosomal gel significantly improved solubility, controlled release, and skin penetration, offering a promising and patient-friendly approach for effective topical antifungal therapy.