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<p>Metallic nanoparticles are being developed both as nanocarriers for current antimicrobial medications and as inherent “nanoantibiotics” to treat lung infections, with inhalable systems showing significant potential for tuberculosis, ventilator-associated pneumonia, acute lung injury, and pneumonia. They are capable of overcoming resistance, improving drug accumulation in the lungs, and reducing systemic toxicity when compared to traditional systemic antibiotics. In this research, cuprous oxide nanoparticles were synthesized using an aqueous extract of <i>Garcinia mangostana</i> as an environmentally friendly method. The synthesized Cu<sub>2</sub>O NPs@<i>Garcinia mangostana</i> were characterized through various techniques, such as XRD, FE-SEM, EDS, TEM, and FT-IR spectroscopy. The average size of the semi-spherical nanoparticles was found to be 31.55 nanometers. The in vivo study encompasses the examination of disease symptoms and the evaluation of the lethal dose of <i>Pseudomonas aeruginosa</i> in mice. The effectiveness of Cu<sub>2</sub>O NPs@<i>Garcinia mangostana</i> in treating lung infections was assessed through calculated lethal dosages, histological analyses, and evaluations of bacteremia. Following a period of 2 days, the body temperature of the untreated animals experienced a significant decrease, falling to 35&#xa0;°C from the initial measurement of 39&#xa0;°C. At the conclusion of the study, a reduction in weight of 30% was also noted. This research entails monitoring reductions in body weight, hypothermia, and bacteremia. The histological analysis revealed a sporadic and extensive accumulation of inflammatory cells within the alveolar gaps; infiltrates were observed in each lung segment of the untreated animals. The objective of this research is to examine the biological properties of Cu<sub>2</sub>O NPs@<i>Garcinia mangostana</i> in order to offer an effective treatment for the lung infection.</p>

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Effect of Green-Synthesized Cuprous Oxide Nanoparticles Using Garcinia mangostana Extract on Pseudomonas aeruginosa–Induced Lung Infection in Mice

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Wenxia Ma,
  • Qi Guo

摘要

Metallic nanoparticles are being developed both as nanocarriers for current antimicrobial medications and as inherent “nanoantibiotics” to treat lung infections, with inhalable systems showing significant potential for tuberculosis, ventilator-associated pneumonia, acute lung injury, and pneumonia. They are capable of overcoming resistance, improving drug accumulation in the lungs, and reducing systemic toxicity when compared to traditional systemic antibiotics. In this research, cuprous oxide nanoparticles were synthesized using an aqueous extract of Garcinia mangostana as an environmentally friendly method. The synthesized Cu2O NPs@Garcinia mangostana were characterized through various techniques, such as XRD, FE-SEM, EDS, TEM, and FT-IR spectroscopy. The average size of the semi-spherical nanoparticles was found to be 31.55 nanometers. The in vivo study encompasses the examination of disease symptoms and the evaluation of the lethal dose of Pseudomonas aeruginosa in mice. The effectiveness of Cu2O NPs@Garcinia mangostana in treating lung infections was assessed through calculated lethal dosages, histological analyses, and evaluations of bacteremia. Following a period of 2 days, the body temperature of the untreated animals experienced a significant decrease, falling to 35 °C from the initial measurement of 39 °C. At the conclusion of the study, a reduction in weight of 30% was also noted. This research entails monitoring reductions in body weight, hypothermia, and bacteremia. The histological analysis revealed a sporadic and extensive accumulation of inflammatory cells within the alveolar gaps; infiltrates were observed in each lung segment of the untreated animals. The objective of this research is to examine the biological properties of Cu2O NPs@Garcinia mangostana in order to offer an effective treatment for the lung infection.