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<p>The present study aims to formulate and optimized mucoadhesive chitosan-coated alginate microbeads as a guardian; encapsulating amoxicillin trihydrate for site specific <i>H. pylori</i> healing in peptic ulcer therapy. This study investigates a gastroretentive mucoadhesive drug delivery method for eliminating <i>H. pylori</i> at specific sites. Using ionotropic gelation, chitosan-coated alginate beads loaded with amoxicillin were formulated and optimized using Box Behnken design, considering concentration of polymer, drug and coating solution as a formulation variable. The optimized bead formulation exhibited <i>in vitro</i> drug release up to 8&#xa0;h, following Korsmeyer-Peppas model. Release mechanism follows non-fictional anomalous transport, 86.54% sustained drug release, 91% to 96.42% entrapment efficiency, and 62–68% mucoadhesion was observed. It was observed that <i>H. pylori</i> could be absolutely eradicated <i>in vitro</i>. Both the SEM and EDAX investigations revealed a rough outer surface with chitosan coating and dense spherical beads, as well as full loading of the element composition. In conclusion, the developed chitosan-coated alginate beads, offers revolutionary possibilities for <i>H. pylori</i> treatment as gastroretentive mucoadhesive system for delivery of amoxicillin. Potentially improve the therapeutic efficacy and reducing the frequency of dose and identifies the effective healing treatment for <i>H. pylori</i> associated ulcer.</p> Graphical Abstract <p></p>

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Ulcer Protective Amoxicillin Trihydrate-loaded Alginate Beads Boosting Ulcer Treatment for Targeted H. Pylori Eradication

  • 期刊论文

  • 发表日期：

    2026年3月10日

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  • Chetan Deore,
  • Santosh Butle,
  • Shailesh Chalikwar,
  • Jayesh Shivaji Patil

摘要

The present study aims to formulate and optimized mucoadhesive chitosan-coated alginate microbeads as a guardian; encapsulating amoxicillin trihydrate for site specific H. pylori healing in peptic ulcer therapy. This study investigates a gastroretentive mucoadhesive drug delivery method for eliminating H. pylori at specific sites. Using ionotropic gelation, chitosan-coated alginate beads loaded with amoxicillin were formulated and optimized using Box Behnken design, considering concentration of polymer, drug and coating solution as a formulation variable. The optimized bead formulation exhibited in vitro drug release up to 8 h, following Korsmeyer-Peppas model. Release mechanism follows non-fictional anomalous transport, 86.54% sustained drug release, 91% to 96.42% entrapment efficiency, and 62–68% mucoadhesion was observed. It was observed that H. pylori could be absolutely eradicated in vitro. Both the SEM and EDAX investigations revealed a rough outer surface with chitosan coating and dense spherical beads, as well as full loading of the element composition. In conclusion, the developed chitosan-coated alginate beads, offers revolutionary possibilities for H. pylori treatment as gastroretentive mucoadhesive system for delivery of amoxicillin. Potentially improve the therapeutic efficacy and reducing the frequency of dose and identifies the effective healing treatment for H. pylori associated ulcer.

Graphical Abstract