Scholarlink

<p>Mupirocin (MuP) is a topical antibiotic effective against a broad range of Gram-positive pathogens, mainly <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>. It is usually prescribed for skin infections caused due to microorganisms like impetigo and superficial topical infections. MuP creams and ointments are usually formulated with polyethylene glycol (PEG) bases. However, they are not advised for use on large wounds or burns, as systemic PEG absorption may occur and cause renal impairment, especially in patients with kidney dysfunction. Hence, in the current research, the oil based (oleogel) topical formulation of MuP was formulated with the elimination of PEG. Additionally, the oleogel combats the problem of the stability of MuP in a water-based base, as it undergoes hydrolysis in the presence of water. The study involved the development of oleogels using Box Behnken Design for optimizing the formulation for adequate hardness, oil binding capacity (OBC), and drug content (DC). The optimized formulation was obtained based on a significant model (<i>p</i> ≤ 0.05). The results of <i>in- vivo</i> study, considering skin irritation and burn wound healing on Wistar albino rats, indicated no signs of skin irritation, ensuring the safety of the formulation. Moreover, the healing of burn wounds was observed progressively over the tested animals with a reduction in wound area. In conclusion, the developed PEG-free MuP oleogel demonstrated enhanced stability, safety, and significant wound-healing efficacy, establishing it as a promising alternative topical formulation for the management of burn and skin infections.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Mupirocin Oleogel for Enhanced Burn Wound Healing Applications: a Preclinical Study

  • 期刊论文

  • 发表日期：

    2026年2月10日

查看全文
  • Sunil Aher,
  • Poonam Patil,
  • Shreya Shevate,
  • Shubham Munde,
  • Popat Mohite,
  • Ketan Ranch,
  • Sudarshan Singh

摘要

Mupirocin (MuP) is a topical antibiotic effective against a broad range of Gram-positive pathogens, mainly Staphylococcus aureus and Staphylococcus epidermidis. It is usually prescribed for skin infections caused due to microorganisms like impetigo and superficial topical infections. MuP creams and ointments are usually formulated with polyethylene glycol (PEG) bases. However, they are not advised for use on large wounds or burns, as systemic PEG absorption may occur and cause renal impairment, especially in patients with kidney dysfunction. Hence, in the current research, the oil based (oleogel) topical formulation of MuP was formulated with the elimination of PEG. Additionally, the oleogel combats the problem of the stability of MuP in a water-based base, as it undergoes hydrolysis in the presence of water. The study involved the development of oleogels using Box Behnken Design for optimizing the formulation for adequate hardness, oil binding capacity (OBC), and drug content (DC). The optimized formulation was obtained based on a significant model (p ≤ 0.05). The results of in- vivo study, considering skin irritation and burn wound healing on Wistar albino rats, indicated no signs of skin irritation, ensuring the safety of the formulation. Moreover, the healing of burn wounds was observed progressively over the tested animals with a reduction in wound area. In conclusion, the developed PEG-free MuP oleogel demonstrated enhanced stability, safety, and significant wound-healing efficacy, establishing it as a promising alternative topical formulation for the management of burn and skin infections.