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Objective <p><i>Urtica dioica</i>, a well-known herbal remedy in traditional and modern medicine, has numerous therapeutic applications. In this specific research, we successfully synthesized Cunano particles using the aqueous extract of <i>U. dioica</i> through a green synthesis method to evaluate the anti-uterine cancer. </p> Method <p>Various techniques were utilized to identify the nanoparticles. A cell viability assay was conducted to evaluate the potential anti-uterine cancer properties of the synthesized nanoparticles.</p> Results <p>XRD and FE-SEM analysis revealed that the Cu NPs had a CuO formula with a spherical morphology measuring less than 50 nm. To assess the level of anti-uterine cancer activity of the nanoparticles, the cell viability test was carried out on HUVEC, CRL-1976, HTB-114, and CRL-1671 cell lines. Additionally, the antioxidant efficacy was assessed using the DPPH assay. The data indicated significant anti-uterine cancer and antioxidant properties of nanoparticles containing <i>U. dioica</i>. The IC50 of CuNPs was 51, 39, and35 μg/ml on CRL-1976, HTB-114, and CRL-1671 uterine cancer cells, respectively. Furthermore, CuNPs were able to inhibit 50% of DPPH at a concentration of 40 μg/mL.</p> Conclusion <p>The synthesized NPs showed acceptable anticancer activity against uterine cancer cell lines.</p>

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Eco-Friendly Synthesis of Copper Oxide Nanoparticles Mediated by Urtica dioica: Potent Antioxidant and Anti-Uterine Cancer Activities

  • 期刊论文

  • 发表日期：

    2026年2月7日

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  • Xiujie Sui,
  • Yuanyuan Liu,
  • Huiming Guo

摘要

Objective

Urtica dioica, a well-known herbal remedy in traditional and modern medicine, has numerous therapeutic applications. In this specific research, we successfully synthesized Cunano particles using the aqueous extract of U. dioica through a green synthesis method to evaluate the anti-uterine cancer.

Method

Various techniques were utilized to identify the nanoparticles. A cell viability assay was conducted to evaluate the potential anti-uterine cancer properties of the synthesized nanoparticles.

Results

XRD and FE-SEM analysis revealed that the Cu NPs had a CuO formula with a spherical morphology measuring less than 50 nm. To assess the level of anti-uterine cancer activity of the nanoparticles, the cell viability test was carried out on HUVEC, CRL-1976, HTB-114, and CRL-1671 cell lines. Additionally, the antioxidant efficacy was assessed using the DPPH assay. The data indicated significant anti-uterine cancer and antioxidant properties of nanoparticles containing U. dioica. The IC50 of CuNPs was 51, 39, and35 μg/ml on CRL-1976, HTB-114, and CRL-1671 uterine cancer cells, respectively. Furthermore, CuNPs were able to inhibit 50% of DPPH at a concentration of 40 μg/mL.

Conclusion

The synthesized NPs showed acceptable anticancer activity against uterine cancer cell lines.