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Background <p>Efficient management of fishery waste is vital for sustainability and pollution control, particularly in India, the world’s second-largest fish producer. This study explores the valorization of Indian fishery waste by extracting chitosan, a versatile bioactive polymer with numerous biomedical applications.</p> Methods <p>Chitosan was derived from chitin extracted from three primary fishery waste sources: rohu fish i.e. (<i>Labeo rohita)</i> scales (RCS), shrimp (<i>Crangon crangon</i>) shells (SCS), and crab (<i>Scylla serrate</i>) shells (CCS) using optimized deacetylation techniques involving 45% NaOH at 90&#xa0;°C under controlled conditions.</p> Results <p>Physical characterizations, such as FTIR, XRD, and DSC, confirmed the structural integrity and thermal stability of the chitosan produced. Among the variants, SCS exhibited the highest degree of deacetylation (86.90 ± 0.09%), superior solubility (84.06 ± 0.11%), and enhanced fat-binding capacity (238.06 ± 0.48%), indicating its potential for pharmaceutical applications. SEM analysis revealed a smoother surface morphology and nanofiber arrangement in SCS. Cytotoxicity assays confirmed SCS chitosan’s biocompatibility, with a 96.45 ± 0.21% cell viability in HACAT cell lines. The antifungal efficacy of SCS underscores its promise as a safe, bioactive material for topical pharmaceutical formulations.</p> Conclusion <p>This study highlights the sustainability of converting fishery waste into high-value chitosan, aligning with circular economy principles. This approach minimizes ecological impact while fostering resource recovery by transforming fishery waste into a valuable biopolymer. Further clinical validation is necessary to confirm its efficacy and safety for broader applications.</p>

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Comparative Analysis of Chitosan from Diverse Indian Fishery Wastes: Characterization and in Vitro Physicochemical and Biological Assessment for Pharmaceutical Uses

  • 期刊论文

  • 发表日期：

    2026年2月14日

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  • Ujjwal Kumar Biswas,
  • Anindya Bose,
  • Sweet Naskar,
  • Shreeja Sen,
  • Saikat Pal

摘要

Background

Efficient management of fishery waste is vital for sustainability and pollution control, particularly in India, the world’s second-largest fish producer. This study explores the valorization of Indian fishery waste by extracting chitosan, a versatile bioactive polymer with numerous biomedical applications.

Methods

Chitosan was derived from chitin extracted from three primary fishery waste sources: rohu fish i.e. (Labeo rohita) scales (RCS), shrimp (Crangon crangon) shells (SCS), and crab (Scylla serrate) shells (CCS) using optimized deacetylation techniques involving 45% NaOH at 90 °C under controlled conditions.

Results

Physical characterizations, such as FTIR, XRD, and DSC, confirmed the structural integrity and thermal stability of the chitosan produced. Among the variants, SCS exhibited the highest degree of deacetylation (86.90 ± 0.09%), superior solubility (84.06 ± 0.11%), and enhanced fat-binding capacity (238.06 ± 0.48%), indicating its potential for pharmaceutical applications. SEM analysis revealed a smoother surface morphology and nanofiber arrangement in SCS. Cytotoxicity assays confirmed SCS chitosan’s biocompatibility, with a 96.45 ± 0.21% cell viability in HACAT cell lines. The antifungal efficacy of SCS underscores its promise as a safe, bioactive material for topical pharmaceutical formulations.

Conclusion

This study highlights the sustainability of converting fishery waste into high-value chitosan, aligning with circular economy principles. This approach minimizes ecological impact while fostering resource recovery by transforming fishery waste into a valuable biopolymer. Further clinical validation is necessary to confirm its efficacy and safety for broader applications.