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<p>This research evaluated the phytochemical composition and investigated the protective potential of an ethanol extract of the marine alga <i>Sargassum polycystum</i> against cisplatin-induced hepatotoxicity and nephrotoxicity in albino rats. Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the extract confirmed the presence of key compounds, including 10-bromodecanoic acid ethyl ester, Z- 26-pentatriacontane-2-one, N-hexadecanoic acid, methyl heptadecanoate, nonadecanoic acid ethyl ester, CIS-11-eicosenoic acid. Toxicity was induced by a single intraperitoneal administration of cisplatin (5&#xa0;mg/kg of body weight) in rat. The intoxicated rats were subsequently treated orally with the <i>S. polycystum</i> extract (250, 350, 450&#xa0;mg/kg of b.wt) for 30 days. Cisplatin administration significantly elevated serum markers of hepatotoxicity (ALT, AST, ALP, total bilirubin, total cholesterol, and triglycerides) and nephrotoxicity (urea, uric acid, and creatinine). Furthermore, the drug caused a substantial decrease in essential electrolytes (Ca, K, Na, P) and total protein levels, accompanied by notable histological disruption in the liver and kidney tissues. Oral supplementation with the <i>S. polycystum</i> extract dose-dependently ameliorated all observed biochemical disturbances, leading to the normalization of elevated enzyme and renal markers when compared to the cisplatin-control group. Histopathological examination also confirmed that the extract restored the structural integrity of the liver and kidney tissues. Additionally, the extract appeared to enhance the immune status of the affected organs. The findings demonstrate potent hepato- and nephroprotective properties of the <i>Sargassum polycystum</i> ethanol extract against cisplatin-induced damage.</p>

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Evaluation of the Protective Effect of Sargassum Polycystum Biomass Derived Byproducts Against Cisplatin Induced Liver and Renal Damage in Albino Rats

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Annamalai Natarajan,
  • Radhakrishnan Prabakarakrishnan,
  • Parthiban Janani,
  • Velayutham Veeramani,
  • Govindaswamy Padmapriya,
  • Balasubramanian Senthil Kumar

摘要

This research evaluated the phytochemical composition and investigated the protective potential of an ethanol extract of the marine alga Sargassum polycystum against cisplatin-induced hepatotoxicity and nephrotoxicity in albino rats. Gas Chromatography-Mass Spectrometry (GC-MS) analysis of the extract confirmed the presence of key compounds, including 10-bromodecanoic acid ethyl ester, Z- 26-pentatriacontane-2-one, N-hexadecanoic acid, methyl heptadecanoate, nonadecanoic acid ethyl ester, CIS-11-eicosenoic acid. Toxicity was induced by a single intraperitoneal administration of cisplatin (5 mg/kg of body weight) in rat. The intoxicated rats were subsequently treated orally with the S. polycystum extract (250, 350, 450 mg/kg of b.wt) for 30 days. Cisplatin administration significantly elevated serum markers of hepatotoxicity (ALT, AST, ALP, total bilirubin, total cholesterol, and triglycerides) and nephrotoxicity (urea, uric acid, and creatinine). Furthermore, the drug caused a substantial decrease in essential electrolytes (Ca, K, Na, P) and total protein levels, accompanied by notable histological disruption in the liver and kidney tissues. Oral supplementation with the S. polycystum extract dose-dependently ameliorated all observed biochemical disturbances, leading to the normalization of elevated enzyme and renal markers when compared to the cisplatin-control group. Histopathological examination also confirmed that the extract restored the structural integrity of the liver and kidney tissues. Additionally, the extract appeared to enhance the immune status of the affected organs. The findings demonstrate potent hepato- and nephroprotective properties of the Sargassum polycystum ethanol extract against cisplatin-induced damage.