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Purpose <p>The present study aims to use central composite design (CCD) to fabricate HPMC/PEO orodispersible nanofibers with optimized nanofiber diameter and mechanical strength.</p> Method <p>The CCD was used for modeling and optimization of the effect of HPMC (2–4%) and PEO (1–3%) concentrations (numerical factors, each one with three levels) and PEO MW (categorical factor with three levels, 300K, 900K, and 2M) based on average nanofiber diameter (in the range of 150–350&#xa0;nm) and mechanical strength (maximize). The optimized formulation was used to fabricate orodispersible films containing risperidone. The drug was dispersed (F1) and dissolved (F2) in polymeric solutions. The nanofibers were characterized in terms of morphology and diameter (by SEM), thermal behavior (using TGA and DSC), crystallinity (using XRD), and mechanical properties (tensile strength). Disintegration time, folding endurance, and drug release were also studied.</p> Result <p>The CCD design showed that a quadratic model predicted nanofiber diameter and a reduced cubic model described mechanical strength. The CCD results revealed that an increase in HPMC/PEO concentrations and PEO MW led to a higher nanofiber diameter. Moreover, for all PEO MWs examined, an increase in PEO concentration corresponded to a reduction in the tensile strength of the nanofibers. HPMC concentration increase positively affected tensile strength at 300K, while this influence became negative at 900K and for most concentration levels at a PEO MW of 2M. The optimized formulation (with the most desirability) was determined to be 2.3% HPMC and 1.3% PEO with 900K MW, with 249.20&#xa0;nm fiber diameter and 16.96&#xa0;MPa mechanical strength. The fabricated optimized formulation showed 243.51±40.12&#xa0;nm diameter and 13.75±2.14&#xa0;MPa tensile strength. Both drug-containing nanofibers (F1 and F2) were uniform and smooth, with appropriate thermal behavior and mechanical properties, and showed no significant differences in diameter. F1 and F2 formulations disintegrated within 5&#xa0;s, with the release of 70% and 91% of loaded drug within 6&#xa0;min, respectively.</p> Conclusion <p>The CCD seems a promising approach for designing nanofibers with optimal characteristics.</p>

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Preparation of HPMC/PEO Blend Nanofibers: Investigating the Impacts of Polymer Concentration and Molecular Weight on Morphological and Mechanical Properties of Electrospun Nanofiber Mats Via Central Composite Design

  • 期刊论文

  • 发表日期：

    2026年1月6日

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  • Shirin Ebrahimi,
  • Arash Mahboubi,
  • Seyed Alireza Mortazavi,
  • Nasrin Zarei Chamgordani,
  • Seyedeh Maryam Mortazavi

摘要

Purpose

The present study aims to use central composite design (CCD) to fabricate HPMC/PEO orodispersible nanofibers with optimized nanofiber diameter and mechanical strength.

Method

The CCD was used for modeling and optimization of the effect of HPMC (2–4%) and PEO (1–3%) concentrations (numerical factors, each one with three levels) and PEO MW (categorical factor with three levels, 300K, 900K, and 2M) based on average nanofiber diameter (in the range of 150–350 nm) and mechanical strength (maximize). The optimized formulation was used to fabricate orodispersible films containing risperidone. The drug was dispersed (F1) and dissolved (F2) in polymeric solutions. The nanofibers were characterized in terms of morphology and diameter (by SEM), thermal behavior (using TGA and DSC), crystallinity (using XRD), and mechanical properties (tensile strength). Disintegration time, folding endurance, and drug release were also studied.

Result

The CCD design showed that a quadratic model predicted nanofiber diameter and a reduced cubic model described mechanical strength. The CCD results revealed that an increase in HPMC/PEO concentrations and PEO MW led to a higher nanofiber diameter. Moreover, for all PEO MWs examined, an increase in PEO concentration corresponded to a reduction in the tensile strength of the nanofibers. HPMC concentration increase positively affected tensile strength at 300K, while this influence became negative at 900K and for most concentration levels at a PEO MW of 2M. The optimized formulation (with the most desirability) was determined to be 2.3% HPMC and 1.3% PEO with 900K MW, with 249.20 nm fiber diameter and 16.96 MPa mechanical strength. The fabricated optimized formulation showed 243.51±40.12 nm diameter and 13.75±2.14 MPa tensile strength. Both drug-containing nanofibers (F1 and F2) were uniform and smooth, with appropriate thermal behavior and mechanical properties, and showed no significant differences in diameter. F1 and F2 formulations disintegrated within 5 s, with the release of 70% and 91% of loaded drug within 6 min, respectively.

Conclusion

The CCD seems a promising approach for designing nanofibers with optimal characteristics.