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Objectives <p>Guided by Quality by Design principles, this study aimed to develop a fluidized bed coating process to prepare curcumin solid dispersion pellets (CUR-SDP) with high flowability, encapsulation efficiency, and content uniformity, and improve curcumin (CUR) solubility and stability.</p> Methods <p>Hansen solubility parameter analysis and anti-crystallization experiments were conducted to select PVP K30 as the optimal carrier. The Plackett-Burman design was used to identify the critical variables affecting CUR-SDP preparation, followed by optimization using the Box-Behnken design to determine the best formulation and process conditions.</p> Results <p>Compared to CUR and the physical mixture, the solubility of CUR-SDP was significantly enhanced. XRD and DSC analysis confirmed that CUR was transformed into an amorphous state during the preparation process and FTIR analysis revealed hydrogen bonding between CUR and PVP K30. Saturated solubility determination showed that CUR-SDP’s thermodynamic dissolution equilibrium concentration was significantly increased, while in vitro dissolution revealed markedly improved dissolution rate. Stability studies confirmed its excellent stability.</p> Conclusions <p>The results demonstrated that CUR-SDP prepared by fluidized bed coating technology significantly enhanced solubility of CUR, while exhibiting excellent flowability and storage stability. The findings suggest that the fluidized bed coating technique is a promising method for preparing CUR-SDP.</p>

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The Fluidized Bed Coating Strategy for Developing Curcumin Solid Dispersion Pellets with Enhanced Solubility and Stability

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Chaoliang Jia,
  • Hao Chang,
  • Taoning Liu,
  • Zijian Zhao,
  • Qingbo Lv,
  • Wenlong Li

摘要

Objectives

Guided by Quality by Design principles, this study aimed to develop a fluidized bed coating process to prepare curcumin solid dispersion pellets (CUR-SDP) with high flowability, encapsulation efficiency, and content uniformity, and improve curcumin (CUR) solubility and stability.

Methods

Hansen solubility parameter analysis and anti-crystallization experiments were conducted to select PVP K30 as the optimal carrier. The Plackett-Burman design was used to identify the critical variables affecting CUR-SDP preparation, followed by optimization using the Box-Behnken design to determine the best formulation and process conditions.

Results

Compared to CUR and the physical mixture, the solubility of CUR-SDP was significantly enhanced. XRD and DSC analysis confirmed that CUR was transformed into an amorphous state during the preparation process and FTIR analysis revealed hydrogen bonding between CUR and PVP K30. Saturated solubility determination showed that CUR-SDP’s thermodynamic dissolution equilibrium concentration was significantly increased, while in vitro dissolution revealed markedly improved dissolution rate. Stability studies confirmed its excellent stability.

Conclusions

The results demonstrated that CUR-SDP prepared by fluidized bed coating technology significantly enhanced solubility of CUR, while exhibiting excellent flowability and storage stability. The findings suggest that the fluidized bed coating technique is a promising method for preparing CUR-SDP.