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Background <p>Lutein, a natural carotenoid with potent antioxidant and anti-inflammatory properties, has shown protective effects in various oxidative stress-related disorders. However, its potential to mitigate doxorubicin, an anthracycline chemotherapeutic agent known to induce atherosclerotic vascular injury, remains poorly understood. This study therefore investigated the protective role of lutein against doxorubicin-induced vascular injury in male Wistar rats.</p> Methods <p>Atherosclerotic vascular injury was induced by intraperitoneal administration of doxorubicin (15&#xa0;mg/kg) for three consecutive days, followed by treatment with lutein (40&#xa0;mg/kg) for 25 days. After day 28, animals were euthanized and aorta removed for biochemical and histological studies. Meanwhile, blood was collected and centrifuged for lipid profile.</p> Results <p>Doxorubicin administration led to increased vascular oxidative stress, inflammation, apoptosis, hyperlipidemia, impaired vascular tone, and loss of endothelial integrity, hallmarks of atherosclerotic injury. Lutein treatment markedly ameliorated these effects by exerting antioxidant, anti-inflammatory, anti-apoptotic, and anti-atherogenic actions. Additionally, lutein enhanced cell adhesion and improved vascular tone, suggesting a role in promoting angiogenesis and endothelial recovery.</p> Conclusion <p>Lutein effectively attenuates doxorubicin-induced atherosclerotic vascular injury in male Wistar rats, likely through modulation of oxidative stress, inflammation, and endothelial repair mechanisms.</p>

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Doxorubicin Therapy is Associated with Atherosclerotic Vascular Injury in Rats: Attenuating Role of Lutein, a Non-Provitamin-A Carotenoid

  • 期刊论文

  • 发表日期：

    2025年11月25日

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  • Jerome Ndudi Asiwe,
  • Jennifer Efe Jaiyeoba-Ojigho,
  • Lauretta Menichim Oshile,
  • Immaculate Ezinne Chijioke,
  • Sonia Oghenetejiri Ransom,
  • Israel Benjamin,
  • Great Ovayero,
  • Emmanuel Ukoha Dike,
  • Agatha Alieze,
  • Victor Oghenekevwe Emmanuel

摘要

Background

Lutein, a natural carotenoid with potent antioxidant and anti-inflammatory properties, has shown protective effects in various oxidative stress-related disorders. However, its potential to mitigate doxorubicin, an anthracycline chemotherapeutic agent known to induce atherosclerotic vascular injury, remains poorly understood. This study therefore investigated the protective role of lutein against doxorubicin-induced vascular injury in male Wistar rats.

Methods

Atherosclerotic vascular injury was induced by intraperitoneal administration of doxorubicin (15 mg/kg) for three consecutive days, followed by treatment with lutein (40 mg/kg) for 25 days. After day 28, animals were euthanized and aorta removed for biochemical and histological studies. Meanwhile, blood was collected and centrifuged for lipid profile.

Results

Doxorubicin administration led to increased vascular oxidative stress, inflammation, apoptosis, hyperlipidemia, impaired vascular tone, and loss of endothelial integrity, hallmarks of atherosclerotic injury. Lutein treatment markedly ameliorated these effects by exerting antioxidant, anti-inflammatory, anti-apoptotic, and anti-atherogenic actions. Additionally, lutein enhanced cell adhesion and improved vascular tone, suggesting a role in promoting angiogenesis and endothelial recovery.

Conclusion

Lutein effectively attenuates doxorubicin-induced atherosclerotic vascular injury in male Wistar rats, likely through modulation of oxidative stress, inflammation, and endothelial repair mechanisms.