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Background <p>Liver diseases include a variety of pathological conditions affecting hepatic tissues, structures, and cellular components. Livopick, is claimed to possess hepatoprotective activity and is used in treating various liver conditions; however, scientific evidence supporting its efficacy is currently lacking. So, the study was designed to evaluate the hepatoprotective potential of the Livopick polyherbal formulation in treating acute experimental liver damage in albino Wistar rats caused by carbon tetrachloride.</p> Methods <p>Wistar rats were divided into various groups: standard control silymarin (100&#xa0;mg/kg), Livopick high dose 150&#xa0;mg/kg, and low dose 100&#xa0;mg/kg, at a dose of 1&#xa0;ml/kg CCl<sub>4</sub> administered orally by diluting with a 1:1 mixture of liquid paraffin on the day 9th of treatment to induce hepatotoxicity. Hepatic markers serum levels (ALT, ALP, AST, Total and direct bilirubin) also tissue antioxidant enzymes (GSH, CAT, SOD) were evaluated. Liver tissue histopathological analysis was conducted.</p> Results <p>CCl<sub>4</sub>showed significant rise in serum ALT, ALP, AST, and bilirubin levels, with a marked reduction in the antioxidant enzyme activity. Pre-treatment with Livopick at both doses significantly restored the biochemical parameters. The higher dose of Livopick has shown to be comparable to silymarin. Histopathological analysis demonstrated the preservation of hepatic structure in the Livopick-treated group.</p> Conclusion <p>Livopick showed significant hepatoprotective activity against CCl₄-induced liver injury, because of antioxidant mechanisms which supports its potential as a therapeutic polyherbal formulation.</p> Graphical Abstract <p></p>

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Assessment of Polyherbal Formulation for Hepatoprotective Activity in Carbon Tetrachloride-Induced Liver Toxicity

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Riyaz Ahmed,
  • Tahreen Taj,
  • Manohar Naik,
  • Md Sadique Hussain,
  • Biplab Debnath,
  • Sumel Ashique,
  • Sathvik Belagodu Sridhar,
  • Sabina Yasmin,
  • Eman Shorog,
  • Md Yousuf Ansari

摘要

Background

Liver diseases include a variety of pathological conditions affecting hepatic tissues, structures, and cellular components. Livopick, is claimed to possess hepatoprotective activity and is used in treating various liver conditions; however, scientific evidence supporting its efficacy is currently lacking. So, the study was designed to evaluate the hepatoprotective potential of the Livopick polyherbal formulation in treating acute experimental liver damage in albino Wistar rats caused by carbon tetrachloride.

Methods

Wistar rats were divided into various groups: standard control silymarin (100 mg/kg), Livopick high dose 150 mg/kg, and low dose 100 mg/kg, at a dose of 1 ml/kg CCl4 administered orally by diluting with a 1:1 mixture of liquid paraffin on the day 9th of treatment to induce hepatotoxicity. Hepatic markers serum levels (ALT, ALP, AST, Total and direct bilirubin) also tissue antioxidant enzymes (GSH, CAT, SOD) were evaluated. Liver tissue histopathological analysis was conducted.

Results

CCl4showed significant rise in serum ALT, ALP, AST, and bilirubin levels, with a marked reduction in the antioxidant enzyme activity. Pre-treatment with Livopick at both doses significantly restored the biochemical parameters. The higher dose of Livopick has shown to be comparable to silymarin. Histopathological analysis demonstrated the preservation of hepatic structure in the Livopick-treated group.

Conclusion

Livopick showed significant hepatoprotective activity against CCl₄-induced liver injury, because of antioxidant mechanisms which supports its potential as a therapeutic polyherbal formulation.

Graphical Abstract