Scholarlink

<p><i>Curcuma xanthorrhiza</i> Roxb. (Javanese turmeric) contains curcumin, a bioactive compound possessed several biological activities including antibacterial. However, its clinical application is limited due to poor water solubility, chemical instability, and low bioavailability. This study aimed to develop, characterize, and evaluate niosomes loaded with <i>C xanthorrhiza</i> extract for enhanced antibacterial activity. Niosomes were prepared using the thin-layer hydration method with varying ratios of Span 60 and cholesterol. These formulations were evaluated for their characteristics, entrapment efficiency (EE), physical stability, in vitro drug release, and antibacterial activity. The optimized formulation F1 containing Span 60 and cholesterol (1:2) showed acceptable % EE (95.27), optimum particle size (10.58&#xa0;μm), the zeta potential was − 79.3 along with a sustained release, displayed a spherical niosome morphology and possessed antibacterial activity against <i>Propionibacterium acnes</i>, <i>Staphylococcus epidermidis</i>, and <i>S. aureus</i> with the Minimum Inhibitory Concentrations (MICs) in the range 78.12 to 312.50&#xa0;µg/mL. The optimized formulation was incorporated into gel. The formulation met the required physical parameters, long storage stability, displayed a more controlled and stable release profile with minimal flux variation. The niosome gel followed the Korsmeyer–Peppas kinetic model, indicating a non-Fickian diffusion mechanism involving both diffusion and polymer matrix relaxation. The gel significantly inhibited the growth of <i>P. acnes</i>, <i>S. epidermidis</i>, and <i>S. aureus</i>. In conclusion, noisome gel demonstrated favorable physicochemical properties, sustained release, improved gel stability and antibacterial performance. This result emphasized the potential of niosomal gels as controlled-release transdermal formulations for acne treatment.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Innovative Niosome Gel Loaded Curcuma Xanthorrhiza Extract: Development Formulation, Characterization, and Evaluation of Their Antibacterial Activity

  • 期刊论文

  • 发表日期：

    2025年11月22日

查看全文
  • Maulida Aminda Luthfi,
  • Intan Tsabitah Husna,
  • Sabrina Dahlizar,
  • Yenny Meliana,
  • Abdi Wira Septama

摘要

Curcuma xanthorrhiza Roxb. (Javanese turmeric) contains curcumin, a bioactive compound possessed several biological activities including antibacterial. However, its clinical application is limited due to poor water solubility, chemical instability, and low bioavailability. This study aimed to develop, characterize, and evaluate niosomes loaded with C xanthorrhiza extract for enhanced antibacterial activity. Niosomes were prepared using the thin-layer hydration method with varying ratios of Span 60 and cholesterol. These formulations were evaluated for their characteristics, entrapment efficiency (EE), physical stability, in vitro drug release, and antibacterial activity. The optimized formulation F1 containing Span 60 and cholesterol (1:2) showed acceptable % EE (95.27), optimum particle size (10.58 μm), the zeta potential was − 79.3 along with a sustained release, displayed a spherical niosome morphology and possessed antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and S. aureus with the Minimum Inhibitory Concentrations (MICs) in the range 78.12 to 312.50 µg/mL. The optimized formulation was incorporated into gel. The formulation met the required physical parameters, long storage stability, displayed a more controlled and stable release profile with minimal flux variation. The niosome gel followed the Korsmeyer–Peppas kinetic model, indicating a non-Fickian diffusion mechanism involving both diffusion and polymer matrix relaxation. The gel significantly inhibited the growth of P. acnes, S. epidermidis, and S. aureus. In conclusion, noisome gel demonstrated favorable physicochemical properties, sustained release, improved gel stability and antibacterial performance. This result emphasized the potential of niosomal gels as controlled-release transdermal formulations for acne treatment.