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<p>The present investigation aimed at development of nanoemulsion of Luliconazole, a broad-spectrum antifungal agent used to treat dermatophytic skin and nail infections. Nanoemulsion was prepared using hot melt emulsification method and further size reduction was accomplished using probe sonication. The developed nanoemulsion was characterized using various tests such as globule size, zeta potential, %drug content, in-vitro release, ex-vivo permeation and cytotoxicity study. The antifungal activity was evaluated using Kirby-Bauer method. The globule size and zeta potential of the Luliconazole nanoemulsion were found to be 237.26 ± 0.35&#xa0;nm -28.54 ± 0.94 mV respectively. There was a high %EE and drug loading of 80.28 ± 1.14% w/w. Comparative efficacy testing showed that developed LZ-NE had higher in-vitro drug release and drug penetration into the nail bed than marketed formulation. Cytotoxicity tests showed no negative effects at the amounts tested. In conclusion, LZ-NE formulation seems to be a promising approach for treatment of superficial fungal infections.</p>

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Development and Topical Efficacy Assessment of Luliconazole Loaded NE for the Treatment of Skin and Nail Fungal Infection

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Darshana Patel,
  • Hetal Thakkar

摘要

The present investigation aimed at development of nanoemulsion of Luliconazole, a broad-spectrum antifungal agent used to treat dermatophytic skin and nail infections. Nanoemulsion was prepared using hot melt emulsification method and further size reduction was accomplished using probe sonication. The developed nanoemulsion was characterized using various tests such as globule size, zeta potential, %drug content, in-vitro release, ex-vivo permeation and cytotoxicity study. The antifungal activity was evaluated using Kirby-Bauer method. The globule size and zeta potential of the Luliconazole nanoemulsion were found to be 237.26 ± 0.35 nm -28.54 ± 0.94 mV respectively. There was a high %EE and drug loading of 80.28 ± 1.14% w/w. Comparative efficacy testing showed that developed LZ-NE had higher in-vitro drug release and drug penetration into the nail bed than marketed formulation. Cytotoxicity tests showed no negative effects at the amounts tested. In conclusion, LZ-NE formulation seems to be a promising approach for treatment of superficial fungal infections.