Scholarlink

Purpose <p>Diabetes mellitus is a prevalent metabolic disorder characterised by disturbances in insulin metabolism and homeostasis. The rising prevalence of diabetes underscores the urgent need of an effective and natural therapeutic agent. Therefore, the present study aimed to investigate the effect of a polyherbal drug, Glymin plus (GM) in a high fat diet (HFD)- streptozotocin (STZ) induced diabetes model.</p> Methods <p>The rats were divided into four groups: normal control, diabetic control receiving HFD-STZ, diabetic rat treated with Metformin, and diabetic treated with Glymin plus (GM) at a specified dose. At the end of the experimental period, rats were euthanized and samples were collected for the analysis of various parameters.</p> Results <p>The results demonstrate that treatment with GM effectively reduced fasting blood glucose level by 73.37% (from 447 ± 7.94&#xa0;mg/dL in diabetic control to 119 ± 4.33&#xa0;mg/dL in GM treated rats) and improved insulin level by 126.90%, likely through inhibiting DPP-4 and enhancing the action of GLP-1 hormone. Furthermore, GM exhibited a protective effect on liver function by regulating liver marker enzymes. The uncontrolled oxidative stress associated with diabetic condition was reduced with GM treatment by restoring the antioxidant enzyme activities. Similarly, the level of pro-inflammatory cytokines such as TNF-α and IL-6 were reduced following GM treatment. Histopathological examination of liver and pancreas tissues revealed that the damage induced by STZ was improved remarkably with GM treatment by maintaining its normal architecture.</p> Conclusion <p>The findings of the present study emphasize the underlying mechanism of Glymin plus as a therapeutic agent for managing diabetes and its associated complications by promoting the activation of GLP-1, subsequently stimulating insulin secretion and thereby regulating blood glucose.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Anti-Diabetic Effect of Herbal Formulation (Glymin Plus) on Experimental Model: Possible Role in GLP-1 Associated Pathway

  • 期刊论文

  • 发表日期：

    2025年7月21日

查看全文
  • S. Sheethal,
  • Svenia P. Jose,
  • M. Ratheesh,
  • Sony Rajan,
  • S. Sandya,
  • Sarala Samuel,
  • Jayashree Madhavan

摘要

Purpose

Diabetes mellitus is a prevalent metabolic disorder characterised by disturbances in insulin metabolism and homeostasis. The rising prevalence of diabetes underscores the urgent need of an effective and natural therapeutic agent. Therefore, the present study aimed to investigate the effect of a polyherbal drug, Glymin plus (GM) in a high fat diet (HFD)- streptozotocin (STZ) induced diabetes model.

Methods

The rats were divided into four groups: normal control, diabetic control receiving HFD-STZ, diabetic rat treated with Metformin, and diabetic treated with Glymin plus (GM) at a specified dose. At the end of the experimental period, rats were euthanized and samples were collected for the analysis of various parameters.

Results

The results demonstrate that treatment with GM effectively reduced fasting blood glucose level by 73.37% (from 447 ± 7.94 mg/dL in diabetic control to 119 ± 4.33 mg/dL in GM treated rats) and improved insulin level by 126.90%, likely through inhibiting DPP-4 and enhancing the action of GLP-1 hormone. Furthermore, GM exhibited a protective effect on liver function by regulating liver marker enzymes. The uncontrolled oxidative stress associated with diabetic condition was reduced with GM treatment by restoring the antioxidant enzyme activities. Similarly, the level of pro-inflammatory cytokines such as TNF-α and IL-6 were reduced following GM treatment. Histopathological examination of liver and pancreas tissues revealed that the damage induced by STZ was improved remarkably with GM treatment by maintaining its normal architecture.

Conclusion

The findings of the present study emphasize the underlying mechanism of Glymin plus as a therapeutic agent for managing diabetes and its associated complications by promoting the activation of GLP-1, subsequently stimulating insulin secretion and thereby regulating blood glucose.