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Purpose <p>Polyvinyl alcohol (PVA), widely used in scaffold fabrication, is valued for its permeability, softness, and transparency, making it ideal for wound-healing applications. This study aims to enhance wound healing by incorporating bioactive compounds, curcumin and wedelolactone, into electrospun PVA nanofibers, leveraging their antioxidant, antibacterial, anti-inflammatory, and analgesic properties.</p> Method <p>Innovative polymeric nanofibrous scaffolds crafted from PVA, curcumin, and wedelolactone have been expertly developed through advanced electrospinning techniques, showcasing their potential in various applications. Scanning Electron Microscopy (SEM), UV–visible spectroscopy, FTIR spectroscopy, X-ray diffraction (XRD), folding endurance tests, and in vitro drug release kinetics were among the methods used to characterize the scaffolds. The scaffolds' ability to promote wound healing was evaluated in vivo using a Wistar albino rat model with excision and incision wound models.</p> Results <p>Characterization techniques confirmed the successful incorporation of curcumin and wedelolactone into the PVA nanofibers. Rats with full-thickness wounds showed in vivo that PVA/Cur/Wed nanofibers healed the wounds on the 13th day compared to the 15th day for the control group, which received commercial povidone ointment. On the 12th day, NS had 18.33 ± 2.19(96.32%) mm2, whereas the control group had 274.16 ± 2.36 (44.65%)mm2, significantly more effective than the control group.</p> Conclusion <p>The results demonstrate that combining curcumin and wedelolactone in PVA nanofibrous scaffolds enhances wound healing, suggesting a potential therapeutic strategy for improving wound care and accelerating recovery in clinical settings.</p> Graphical Abstract <p></p>

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Development and Assessment of Electrospun Nanofibrous Wound Dressing Containing Curcumin and Wedelolactone

  • 期刊论文

  • 发表日期：

    2025年7月2日

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  • Deepika Sharma,
  • Shriyansh Srivastava,
  • Sachin Kumar,
  • Abdul Rahaman,
  • Rupali Sharma,
  • Vipin Kumar Garg,
  • Sumel Ashique,
  • Siva Prasad Panda,
  • Uttam Prasad Panigrahy,
  • Sabina Yasmin,
  • Kumar Venkatesan,
  • Mohammad Yousuf Ansari

摘要

Purpose

Polyvinyl alcohol (PVA), widely used in scaffold fabrication, is valued for its permeability, softness, and transparency, making it ideal for wound-healing applications. This study aims to enhance wound healing by incorporating bioactive compounds, curcumin and wedelolactone, into electrospun PVA nanofibers, leveraging their antioxidant, antibacterial, anti-inflammatory, and analgesic properties.

Method

Innovative polymeric nanofibrous scaffolds crafted from PVA, curcumin, and wedelolactone have been expertly developed through advanced electrospinning techniques, showcasing their potential in various applications. Scanning Electron Microscopy (SEM), UV–visible spectroscopy, FTIR spectroscopy, X-ray diffraction (XRD), folding endurance tests, and in vitro drug release kinetics were among the methods used to characterize the scaffolds. The scaffolds' ability to promote wound healing was evaluated in vivo using a Wistar albino rat model with excision and incision wound models.

Results

Characterization techniques confirmed the successful incorporation of curcumin and wedelolactone into the PVA nanofibers. Rats with full-thickness wounds showed in vivo that PVA/Cur/Wed nanofibers healed the wounds on the 13th day compared to the 15th day for the control group, which received commercial povidone ointment. On the 12th day, NS had 18.33 ± 2.19(96.32%) mm2, whereas the control group had 274.16 ± 2.36 (44.65%)mm2, significantly more effective than the control group.

Conclusion

The results demonstrate that combining curcumin and wedelolactone in PVA nanofibrous scaffolds enhances wound healing, suggesting a potential therapeutic strategy for improving wound care and accelerating recovery in clinical settings.

Graphical Abstract