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Purpose <p>The study aimed to develop liquid dressings containing copper nanoparticles infused with vanillic acid to enhance their&#xa0;antibacterial properties.</p> Method <p>PEG 6000 served as a stabilising agent in the chemical reduction process. The Box-Behnken design was employed to optimise the synthesised nanoparticles. Vanillic acid, obtained from Vanilla planifolia, possesses medicinal qualities, promoting wound healing and antioxidant properties. The nanoparticles were integrated into an optimised batch of in-situ film (liquid dressing) and assessed using DSC, FESEM, cytotoxicity analysis, and in-vivo testing.</p> Result <p>The optimised batch exhibited an entrapment effectiveness of 90.9%, an in-vitro drug release of 89.6%, a particle size of 97.9 nm, a zeta potential of -31 mV, and a polydispersity index of 0.316.</p> Conclusion <p>The liquid dressing exhibited superior wound healing capabilities compared to&#xa0;the pure Vanillic acid solution.</p> Graphical Abstract <p></p>

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Colloidal Copper Nanoparticles Loaded with Vanillic Acid as Liquid Dressings: Development, Characterisation and Evaluation

  • 期刊论文

  • 发表日期：

    2025年3月6日

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  • Mohini Yadav,
  • Neelam Datt,
  • Priyanka Maurya,
  • Vishwambhar Mishra,
  • Shailendra K. Saraf

摘要

Purpose

The study aimed to develop liquid dressings containing copper nanoparticles infused with vanillic acid to enhance their antibacterial properties.

Method

PEG 6000 served as a stabilising agent in the chemical reduction process. The Box-Behnken design was employed to optimise the synthesised nanoparticles. Vanillic acid, obtained from Vanilla planifolia, possesses medicinal qualities, promoting wound healing and antioxidant properties. The nanoparticles were integrated into an optimised batch of in-situ film (liquid dressing) and assessed using DSC, FESEM, cytotoxicity analysis, and in-vivo testing.

Result

The optimised batch exhibited an entrapment effectiveness of 90.9%, an in-vitro drug release of 89.6%, a particle size of 97.9 nm, a zeta potential of -31 mV, and a polydispersity index of 0.316.

Conclusion

The liquid dressing exhibited superior wound healing capabilities compared to the pure Vanillic acid solution.

Graphical Abstract