A new species in the recently re-circumscribed genus Distimake (Convolvulaceae) is here described. Distimake caespitosus is currently known only from Brazil, restricted to the Cerrado domain, in the states of Distrito Federal, Goiás, and Minas Gerais. The species is characterized by an erect habit with several short erect stems, sub-sessile tri-foliolate leaves, and a villous indumentum composed of a mix of simple and 2–5-stellate hairs, covering stems and leaves. Out of the 53 species now recognized in Distimake, this is the fourth that is known with an erect habit, all four restricted to the Neotropical region. We here present a full description of this new species with illustrations, as well as comments on geographic distribution, conservation status, and systematics.