Quipuanthus calcaratus, a new species of Melastomataceae (Cyphostyleae) known only from the type locality in an inter-Andean valley of the Colombian Central Andes, is described and illustrated. This new species is the second for the genus and can be distinguished from Q. epipetricus by its shorter petioles, leaf blades with three pairs of secondary basal veins with the outermost pair imperfectly acrodromous and distally semicraspedrodromous, hypanthium terete, anther connective with a dorsal appendage prolonged into an acute, curved spur, and style straight and longer than the type species of the genus. This novelty is the first species of the genus found in Colombia rather than the eastern slopes of the Andes from Ecuador and Peru, as the previously described Q. epipectricus.
