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<p>The rise of antimicrobial resistance represents a major threat to global health, highlighting the urgent need for novel antimicrobial agents. <i>Fomitopsis pinicola</i>, a wood-decaying fungus commonly found in coniferous forests, has attracted increasing attention as a potential source of bioactive compounds with antimicrobial activity. Over the past decade, approximately 150 compounds, predominantly lanostane-triterpenoids, have been isolated from <i>F. pinicola</i>, with 18 compounds evaluated for their antimicrobial activity. Additional classes of bioactive constituents, including phenolic compounds, polysaccharides, and fatty acids, further contribute to its broad-spectrum antimicrobial potential. Despite the limited number of experimental studies, <i>F. pinicola</i> extracts have demonstrated notable in vitro activity against highly resistant bacterial pathogens, including methicillin-resistant <i>Staphylococcus aureus</i>, vancomycin-resistant <i>Enterococcus faecium</i>, and erythromycin-resistant <i>Streptococcus pyogenes</i>, as well as clinically relevant fungal species such as <i>Candida albicans</i> and <i>Aspergillus fumigatus</i>. Nevertheless, the antimicrobial potential of <i>F. pinicola</i> remains insufficiently explored, as the mechanisms of action and possible synergistic interactions among its bioactive constituents are still poorly understood. The aim of this review is to critically examine the chemical diversity of antimicrobial compounds reported from <i>F. pinicola</i>, summarize the current evidence regarding their antimicrobial activities, and highlight key limitations related to mechanistic insight, synergistic effects, and reproducibility. By integrating fragmented findings, this review seeks to clarify the relevance of <i>F. pinicola</i> as a promising natural source of antimicrobial agents within the broader context of rising antimicrobial resistance.</p>

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The antimicrobial potential of Fomitopsis Pinicola across multiple applications

  • 期刊论文

  • 发表日期：

    2026年2月27日

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  • Sofia Zazouli,
  • Nysrine Mannani

摘要

The rise of antimicrobial resistance represents a major threat to global health, highlighting the urgent need for novel antimicrobial agents. Fomitopsis pinicola, a wood-decaying fungus commonly found in coniferous forests, has attracted increasing attention as a potential source of bioactive compounds with antimicrobial activity. Over the past decade, approximately 150 compounds, predominantly lanostane-triterpenoids, have been isolated from F. pinicola, with 18 compounds evaluated for their antimicrobial activity. Additional classes of bioactive constituents, including phenolic compounds, polysaccharides, and fatty acids, further contribute to its broad-spectrum antimicrobial potential. Despite the limited number of experimental studies, F. pinicola extracts have demonstrated notable in vitro activity against highly resistant bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and erythromycin-resistant Streptococcus pyogenes, as well as clinically relevant fungal species such as Candida albicans and Aspergillus fumigatus. Nevertheless, the antimicrobial potential of F. pinicola remains insufficiently explored, as the mechanisms of action and possible synergistic interactions among its bioactive constituents are still poorly understood. The aim of this review is to critically examine the chemical diversity of antimicrobial compounds reported from F. pinicola, summarize the current evidence regarding their antimicrobial activities, and highlight key limitations related to mechanistic insight, synergistic effects, and reproducibility. By integrating fragmented findings, this review seeks to clarify the relevance of F. pinicola as a promising natural source of antimicrobial agents within the broader context of rising antimicrobial resistance.