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<p>Biofilm formation, especially in medical devices, is a pertinent factor in the virulence of <i>Staphylococcus aureus</i>, and is known to increase morbidity, mortality, and costs. We evaluated the activity of paroxetine, a selective serotonin reuptake inhibitor, alone and associated with oxacillin, a β-lactam antibacterial, against <i>S. aureus</i> biofilms, as well as verified its potential application as a preventive agent against biofilm formation in catheters. The tests were performed against mature and developing biofilms of methicillin-sensitive and -resistant <i>S. aureus</i> using the thiazolyl blue tetrazolium bromide reduction assay. The prevention of biofilm formation in catheters was investigated by counting colony-forming units, and scanning electron microscopy was also performed. Paroxetine caused a significant reduction in cell viability in biofilms, and when associated with oxacillin, significance was verified. Paroxetine alone and associated with oxacillin showed potential for preventing the formation of <i>S. aureus</i> biofilms in peripheral venous catheters, demonstrated by scanning electron microscopy, reaching inhibition of 94.94% in colony-forming units per mL. Paroxetine demonstrated promising potential against <i>S. aureus</i> biofilms in vitro, indicating the possibility of application as a protective agent against the formation of <i>S. aureus</i> biofilms in catheters.</p>

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Potential activity of paroxetine alone and associated with oxacillin as an alternative to prevent Staphylococcus aureus biofilm formation in catheters

  • 期刊论文

  • 发表日期：

    2025年3月28日

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  • Vitória Pessoa de Farias Cabral,
  • Daniel Sampaio Rodrigues,
  • Amanda Dias Barbosa,
  • Lara Elloyse Almeida Moreira,
  • Lívia Gurgel do Amaral Valente Sá,
  • Francisca Bruna Stefany Aires do Nascimento,
  • Cecília Rocha da Silva,
  • João Batista de Andrade Neto,
  • Beatriz Oliveira de Souza,
  • Marina Duarte Pinto Lobo,
  • Manoel Odorico de Moraes,
  • Hélio Vitoriano Nobre Júnior

摘要

Biofilm formation, especially in medical devices, is a pertinent factor in the virulence of Staphylococcus aureus, and is known to increase morbidity, mortality, and costs. We evaluated the activity of paroxetine, a selective serotonin reuptake inhibitor, alone and associated with oxacillin, a β-lactam antibacterial, against S. aureus biofilms, as well as verified its potential application as a preventive agent against biofilm formation in catheters. The tests were performed against mature and developing biofilms of methicillin-sensitive and -resistant S. aureus using the thiazolyl blue tetrazolium bromide reduction assay. The prevention of biofilm formation in catheters was investigated by counting colony-forming units, and scanning electron microscopy was also performed. Paroxetine caused a significant reduction in cell viability in biofilms, and when associated with oxacillin, significance was verified. Paroxetine alone and associated with oxacillin showed potential for preventing the formation of S. aureus biofilms in peripheral venous catheters, demonstrated by scanning electron microscopy, reaching inhibition of 94.94% in colony-forming units per mL. Paroxetine demonstrated promising potential against S. aureus biofilms in vitro, indicating the possibility of application as a protective agent against the formation of S. aureus biofilms in catheters.