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<p>A super-tough polyglycolide-<i>b</i>-poly(L-)lactide-<i>b</i>-polyglycolide (<i>b</i>-PLLGA) triblock copolymer was prepared without sacrificing the excellent intrinsic mechanical strength of <i>b</i>-PLLGA. The material was fabricated in a sustainable manner using a simple one-pot conventional ring-opening (ROP) technique with 30&#xa0;mol% glycolide and (L-)-lactide. Thermal, microstructural, and mechanical properties of the copolymer were characterized and subsequently compared with those of <i>homo</i>-PLLA and random poly(L-)lactide-co-glycolide (<i>r-</i>PLLGA) with a similar molar ratio. The obtained results confirmed that <i>b</i>-PLLGA exhibits higher thermal stability and mechanical strength than homo-PLLA and <i>r</i>-PLLGA. Compared to <i>r</i>-PLLGA, <i>b</i>-PLLGA shows a block-type microstructure as well as two glass transitions and two melt transitions attributed to blocks of polyglycolide and polylactide, respectively. Three types of toughening agents with different branching structures were prepared to investigate the effect of branching structure on toughening of <i>b</i>-PLLGA. From tensile testing, significant elongation up to 55% prior to fracture was observed for <i>b</i>-PLLGA with addition of a small amount of toughening agent (up to 5%), while the excellent intrinsic tensile strength of the copolymer was preserved. PLLA on the other hand shows an elongation at break up to 270% with 15% addition of PCL-b-PLLA-grafted GO-based modifier. The adopted approach is highly convenient to obtain mechanically strong b-PLLGA-based biomaterials.</p>

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Super-Tough Polyglycolide-Based A-B-A-Type Triblock Copolymer: A New Sustainable Approach Toward Mechanically Strong Biomaterials

  • 期刊论文

  • 发表日期：

    2026年7月14日

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  • Muhammad Ayyoob,
  • Young Jun Kim,
  • Fiaz Hussain

摘要

A super-tough polyglycolide-b-poly(L-)lactide-b-polyglycolide (b-PLLGA) triblock copolymer was prepared without sacrificing the excellent intrinsic mechanical strength of b-PLLGA. The material was fabricated in a sustainable manner using a simple one-pot conventional ring-opening (ROP) technique with 30 mol% glycolide and (L-)-lactide. Thermal, microstructural, and mechanical properties of the copolymer were characterized and subsequently compared with those of homo-PLLA and random poly(L-)lactide-co-glycolide (r-PLLGA) with a similar molar ratio. The obtained results confirmed that b-PLLGA exhibits higher thermal stability and mechanical strength than homo-PLLA and r-PLLGA. Compared to r-PLLGA, b-PLLGA shows a block-type microstructure as well as two glass transitions and two melt transitions attributed to blocks of polyglycolide and polylactide, respectively. Three types of toughening agents with different branching structures were prepared to investigate the effect of branching structure on toughening of b-PLLGA. From tensile testing, significant elongation up to 55% prior to fracture was observed for b-PLLGA with addition of a small amount of toughening agent (up to 5%), while the excellent intrinsic tensile strength of the copolymer was preserved. PLLA on the other hand shows an elongation at break up to 270% with 15% addition of PCL-b-PLLA-grafted GO-based modifier. The adopted approach is highly convenient to obtain mechanically strong b-PLLGA-based biomaterials.