<p>This study explores the impact of fabric structural properties such as loop density, yarn count, and elastane content on the electrical performance of knitted textile electrodes under extension and bending. Resistance and signal amplitude measurements were analyzed as primary response variables, and statistical significance was evaluated using ANOVA. The findings indicated that both resistance and amplitude were found to be significantly influenced by the selected parameters under longitudinal extension and bending. It was observed that yarn count and elastane content have dominant effects. Several two-way interactions, particularly between elastane and extension type, also have notable impacts, highlighting the interplay between material composition and mechanical strain. In contrast, under transverse extension, only the resistance was significantly affected, mainly due to the elastane content, while the amplitude remained constant in all configurations. This indicates that the signal acquisition is strong. These findings demonstrate that both individual design factors and their interactions critically influence the electrical behavior of textile electrodes.</p>