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<p>Hemodialysis membranes require controlled microstructure, surface characteristics, and mechanical stability to ensure reliable performance in blood-contacting environments. In this study, polyethersulfone (PES)-based polymer/inorganic composite membranes incorporating zeolite Y were fabricated via nonsolvent-induced phase separation (NIPS) to investigate concentration-dependent structure, property relationships. The incorporation of zeolite Y preserved the characteristic finger-like morphology of PES membranes while enhancing surface hydrophilicity and mechanical strength. Systematic physicochemical characterization demonstrated that increasing zeolite Y content modulated pore structure and wettability without inducing significant structural disruption. Functional validation through simulated dialysis showed that urea and creatinine removal efficiencies increased from 15.92 to 48.89% and from 15.42 to 50.66%, respectively, while maintaining controlled bovine serum albumin loss. In addition, LDH assays indicated cell viability above 80% for all composite membranes, confirming favorable cytocompatibility. These results highlight the potential of zeolite Y as a functional inorganic additive in PES-based mixed-matrix systems and provide insight into the rational design of polymer composite membranes for biomedical applications.</p>

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Characterization of Polyethersulfone Zeolite Y Hemodialysis Membranes Prepared via Nonsolvent-Induced Phase Separation

  • 期刊论文

  • 发表日期：

    2026年3月21日

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  • Gyeong Tae Lee,
  • So Yun Heo,
  • Young Ki Hong

摘要

Hemodialysis membranes require controlled microstructure, surface characteristics, and mechanical stability to ensure reliable performance in blood-contacting environments. In this study, polyethersulfone (PES)-based polymer/inorganic composite membranes incorporating zeolite Y were fabricated via nonsolvent-induced phase separation (NIPS) to investigate concentration-dependent structure, property relationships. The incorporation of zeolite Y preserved the characteristic finger-like morphology of PES membranes while enhancing surface hydrophilicity and mechanical strength. Systematic physicochemical characterization demonstrated that increasing zeolite Y content modulated pore structure and wettability without inducing significant structural disruption. Functional validation through simulated dialysis showed that urea and creatinine removal efficiencies increased from 15.92 to 48.89% and from 15.42 to 50.66%, respectively, while maintaining controlled bovine serum albumin loss. In addition, LDH assays indicated cell viability above 80% for all composite membranes, confirming favorable cytocompatibility. These results highlight the potential of zeolite Y as a functional inorganic additive in PES-based mixed-matrix systems and provide insight into the rational design of polymer composite membranes for biomedical applications.