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<p>Gelatin has been widely employed as a biomaterial for wound dressing fabrication owing to its excellent biocompatibility. However, its applications are limited by structural instability and lack of multifunctionality. To address these limitations, we developed a novel tannic acid/gelatin/sodium alginate (TA/Gel/SA) composite hydrogel through hydrogen bonding and Michael addition reactions under alkaline conditions. Comprehensive characterization revealed that the incorporation of tannic acid at a concentration of 0.6 wt% significantly enhanced the hydrogel's cross-linking density and mechanical strength. Furthermore, the modified hydrogel exhibited remarkable antibacterial properties with an inhibition zone diameter of 42.5&#xa0;mm and antioxidant properties with a radical scavenging rate of 75%, along with substantially improved blood coagulation capability. The material demonstrated an acceptable hemolysis rate, meeting essential requirements for wound care applications. With its superior biocompatibility and multifunctional performance, this TA/Gel/SA hydrogel shows promising potential for biomedical applications, particularly in advanced wound management systems.</p>

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Tannic Acid/Gelatin/Sodium Alginate Multifunctional Composite Hydrogels with Biocompatible and Antibacterial Properties

  • 期刊论文

  • 发表日期：

    2025年10月9日

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  • Que Kong,
  • Xinyi Hu,
  • Yilin Wu,
  • Zhiguang Li

摘要

Gelatin has been widely employed as a biomaterial for wound dressing fabrication owing to its excellent biocompatibility. However, its applications are limited by structural instability and lack of multifunctionality. To address these limitations, we developed a novel tannic acid/gelatin/sodium alginate (TA/Gel/SA) composite hydrogel through hydrogen bonding and Michael addition reactions under alkaline conditions. Comprehensive characterization revealed that the incorporation of tannic acid at a concentration of 0.6 wt% significantly enhanced the hydrogel's cross-linking density and mechanical strength. Furthermore, the modified hydrogel exhibited remarkable antibacterial properties with an inhibition zone diameter of 42.5 mm and antioxidant properties with a radical scavenging rate of 75%, along with substantially improved blood coagulation capability. The material demonstrated an acceptable hemolysis rate, meeting essential requirements for wound care applications. With its superior biocompatibility and multifunctional performance, this TA/Gel/SA hydrogel shows promising potential for biomedical applications, particularly in advanced wound management systems.