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<p>This study investigates the synergistic effects of the incorporation of salicylic acid (SA) and nano-zinc oxide (ZnO) on the physicochemical and antibacterial properties of polylactic acid (PLA)/polyvinylpyrrolidone (PVP)-based nanofiber membranes fabricated via electrospinning. The results indicate that the introduction of SA significantly enhances the solution conductivity and thermal stability of the nanofiber membranes, while effectively promoting the uniform distribution of ZnO nanoparticles within the fiber matrix. On the other hand, the addition of ZnO increases the solution viscosity, elevates the thermal decomposition activation energy, boosts the residual carbon content, and modulates the release rate of SA, achieving approximately 90% sustained release within 8&#xa0;days in accordance with Fick diffusion. At the optimized loading concentration of 2% SA and 2% ZnO, the nanofiber membranes exhibit optimal mechanical properties, with an increased elongation at break of 88% and a tensile strength reaching 2.3&#xa0;MPa. Although both SA and ZnO possess certain hydrophobic properties, leading to a slight decrease in the hydrophilicity of the fiber membranes, the composite composition under this condition demonstrates the most superior overall performance. Antibacterial test results reveal that PLA/PVP drug-loaded fiber membranes containing 2% SA and 2% ZnO exhibit strong inhibitory effects against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, with inhibition zones increasing to 14.0&#xa0;mm and 13.2&#xa0;mm, respectively. Furthermore, cytotoxicity evaluations further confirm that the fiber membranes loaded with SA and ZnO possess high cell viability and excellent cell compatibility, suggesting their broad application potential in the biomedical field.</p>

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Electrospinning Polylactic Acid-Based Antibacterial Membranes for Wound Dressings: Synergistic Influence of Salicylic Acid and ZnO

  • 期刊论文

  • 发表日期：

    2025年9月16日

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  • Rui Tie,
  • Sudan Zhou,
  • Zixuan Liu,
  • Yansong Huang,
  • Ee Wang,
  • Yujuan Jin,
  • Huafeng Tian,
  • Hua Wu,
  • Yunxuan Weng

摘要

This study investigates the synergistic effects of the incorporation of salicylic acid (SA) and nano-zinc oxide (ZnO) on the physicochemical and antibacterial properties of polylactic acid (PLA)/polyvinylpyrrolidone (PVP)-based nanofiber membranes fabricated via electrospinning. The results indicate that the introduction of SA significantly enhances the solution conductivity and thermal stability of the nanofiber membranes, while effectively promoting the uniform distribution of ZnO nanoparticles within the fiber matrix. On the other hand, the addition of ZnO increases the solution viscosity, elevates the thermal decomposition activation energy, boosts the residual carbon content, and modulates the release rate of SA, achieving approximately 90% sustained release within 8 days in accordance with Fick diffusion. At the optimized loading concentration of 2% SA and 2% ZnO, the nanofiber membranes exhibit optimal mechanical properties, with an increased elongation at break of 88% and a tensile strength reaching 2.3 MPa. Although both SA and ZnO possess certain hydrophobic properties, leading to a slight decrease in the hydrophilicity of the fiber membranes, the composite composition under this condition demonstrates the most superior overall performance. Antibacterial test results reveal that PLA/PVP drug-loaded fiber membranes containing 2% SA and 2% ZnO exhibit strong inhibitory effects against Escherichia coli and Staphylococcus aureus, with inhibition zones increasing to 14.0 mm and 13.2 mm, respectively. Furthermore, cytotoxicity evaluations further confirm that the fiber membranes loaded with SA and ZnO possess high cell viability and excellent cell compatibility, suggesting their broad application potential in the biomedical field.