<p>Matrine, a natural fungicide derived from legumes, exhibits significant antibacterial and antifungal activities against <i>Escherichia coli</i><i>, </i><i>Staphylococcus aureus</i>, and <i>Candida albicans</i>. Matrine-loaded agar microcapsules were synthesized utilizing the emulsification technique. Under conditions where the stirring speed was set at 10,000&#xa0;rpm, the core-to-wall ratio was maintained at 1:5, and the emulsification temperature was established at 80&#xa0;°C, the microcapsules exhibited a drug loading efficiency of 15.1% and an encapsulation efficiency of 75.6%. These microcapsules were subsequently affixed to cotton fibers using waterborne polyurethane, resulting in an antibacterial cotton fabric(Matrine@Agar/Cot) capable of inhibiting the proliferation of <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i> to a significant degree. The warp breaking strength of Matrine@Agar/Cot decreased by 1%, the weft breaking strength decreased by 6.3%, and the air permeability decreased by 5%, while the mechanical strength and air permeability of the fabric remained largely unchanged. The antibacterial rates of Matrine@Agar/Cot against <i>E. coli</i>, <i>S. aureus</i>, and <i>Candida albicans</i> were 73.9%, 72.5%, and 80.0%, respectively. After 10 washing cycles, these rates decreased to 66.7%, 51.6%, and 59.5%, respectively. After 30 and 40 washes, Matrine@Agar/Cot could not produce an inhibitory effect on <i>E.coli, S.aureus</i>, and <i>Candida albicans.</i></p> Graphical abstract <p></p>

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Preparation of Antibacterial Microcapsules Loaded with Matrine and the Application to Cotton Fabrics

  • Chaojun Li,
  • Guozhu Tong,
  • Ninghao Fang,
  • Man Zhou,
  • Bo Xu,
  • Ying Liu

摘要

Matrine, a natural fungicide derived from legumes, exhibits significant antibacterial and antifungal activities against Escherichia coli, Staphylococcus aureus, and Candida albicans. Matrine-loaded agar microcapsules were synthesized utilizing the emulsification technique. Under conditions where the stirring speed was set at 10,000 rpm, the core-to-wall ratio was maintained at 1:5, and the emulsification temperature was established at 80 °C, the microcapsules exhibited a drug loading efficiency of 15.1% and an encapsulation efficiency of 75.6%. These microcapsules were subsequently affixed to cotton fibers using waterborne polyurethane, resulting in an antibacterial cotton fabric(Matrine@Agar/Cot) capable of inhibiting the proliferation of Escherichia coli, Staphylococcus aureus, and Candida albicans to a significant degree. The warp breaking strength of Matrine@Agar/Cot decreased by 1%, the weft breaking strength decreased by 6.3%, and the air permeability decreased by 5%, while the mechanical strength and air permeability of the fabric remained largely unchanged. The antibacterial rates of Matrine@Agar/Cot against E. coli, S. aureus, and Candida albicans were 73.9%, 72.5%, and 80.0%, respectively. After 10 washing cycles, these rates decreased to 66.7%, 51.6%, and 59.5%, respectively. After 30 and 40 washes, Matrine@Agar/Cot could not produce an inhibitory effect on E.coli, S.aureus, and Candida albicans.

Graphical abstract