<p>In recent years, the yarn of more knitted fabrics on the market is cotton, and there are also comfortable skin-friendly knitted fabrics from silk, cashmere, and bamboo pulp fibers. To improve the fabric touch, air permeability, and appearance texture, this study explores the four different blended yarns made from silk, cashmere, and bamboo pulp fibers as the raw material, tests and mathematically analyzes the performance of the four blended yarns. We select the appropriate blended yarns, and the knitted fabrics are produced using a TF-S3F4 single-sided weft circular knitting machine, followed by sanding. The durability, comfort, and dimensional stability of the fabrics were explored, and orthogonal experiments were carried out to analyze and determine the blended yarns knitted into fabrics optimal process combination. The results showed that the moisture content of the four blended yarns surpassed 7.5%, with moisture regain rates exceeding 8.5%, suggesting exceptional moisture absorption capabilities. Among the four, the cotton/spun silk blended yarn excels in comprehensive performance. An increase in the grinding rate enhances the fabric’s air permeability, while higher total density results in lower permeability. Through meticulous orthogonal experimentation and analysis, we identified the optimal technology combination for grinding knitted fabric as A2B3C3, which provided a theoretical basis for the preparation of new frosted knitted fabrics.</p>