This paper investigates periodic solutions for semilinear partial differential equations in the whole space \(\mathbb {R}^n\) \((n\ge 3)\) and develops an application to a singular quasilinear elliptic problem. Motivated by the influence of temporal periodicity on nonlinear dynamics, we introduce a framework based on Lyapunov-type ordered barriers and a monotone time-T iteration for the associated parabolic evolution. We first implement the method in the three-dimensional setting \(\mathbb {R}^3\) , where we establish the existence of time-periodic solutions under general structural assumptions on the nonlinearity. We then extend the construction to higher dimensions \(\mathbb {R}^n\) with \(n>3\) , demonstrating that the approach is robust with respect to the spatial dimension. As an application, we study a singular quasilinear elliptic problem of p-Laplacian type with a parametric reaction term and a singular contribution. We embed the elliptic equation into a corresponding autonomous parabolic flow and exploit an energy dissipation identity to relate time-T periodic solutions of the flow to equilibria, thereby obtaining at least one positive weak solution. We further establish multiplicity of solutions via a variational argument based on a Nehari-type decomposition. These results provide insight into the existence and multiplicity mechanisms for nonlinear PDEs with singular structures.