Let \(\mathbb {k}=\mathbb {Q}(\sqrt{p_{1}p_{2}q_{1}q_{2}})\) be a real quadratic number field, where \(p_{i}\equiv -q_{i}\equiv 1 \pmod 4\) , \(i=1, 2\) , are different prime integers and \(\textrm{C}_{\mathbb {k}, 2}\) its 2-class group. Let \(\mathbb {k}_2^{(1)}\) (resp. \(\mathbb {k}_2^{(2)}\) ) be the first (resp. second) Hilbert 2-class field of \(\mathbb {k}\) . In this article, we investigate the metacyclicity of \(G=Gal(\mathbb {k}_{2}^{(2)}/\mathbb {k})\) and the cyclicity of \(G'=Gal(\mathbb {k}_{2}^{(2)}/\mathbb {k}_{2}^{(1)})\) , the derived subgroup of G, assuming \(\textrm{C}_{\mathbb {k}, 2}\simeq G/G'\simeq \mathbb {Z}/2\mathbb {Z}\times \mathbb {Z}/2^{n}\mathbb {Z}\) , with \(n\ge 2\) . As application we study the capitulation of \(\textrm{C}_{\mathbb {k}, 2}\) in the quadratic and biquadratic subfields of \(\mathbb {k}_{2}^{(1)}\) .