Let R be a prime ring of characteristic different from 2, \(Q_r\) be its right Martindale quotient ring and C be its extended centroid. Suppose that F is a non-zero b-generalized skew derivation of R, L a non-central Lie ideal of R and \(n\ge 1\) a fixed positive integer such that \(\biggl (F(x)x\biggr )^n \in Z(R)\) , for all \(x\in L\) . If either \(char(R)=0\) or \(0\ne char(R)=p \ge n+1\) , then \(R\subseteq M_2(K)\) , the \(2\times 2\) matrix ring over a field K.