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<p>Artificial sweeteners have become essential in contemporary diets as alternatives to sugar to combat health issues like obesity and diabetes. Neotame, a structurally modified derivative of aspartame, has received global regulatory clearance owing to its exceptional sweetness, metabolic efficacy, and chemical stability. This paper thoroughly analyses neotame’s physicochemical characteristics, metabolic pathways, toxicological profile, and possible effects on human health. Data from animal models, in vitro experiments, and restricted human clinical investigations consistently provide a favourable safety profile, with zero bioaccumulation risk and minimal environmental persistence relative to other sweeteners. Moreover, neotame’s rapid metabolism diminishes methanol synthesis, making it suitable for individuals with phenylketonuria within prescribed consumption limits. However, concerns persist about the long-term metabolic and microbiome consequences, indirect environmental exposure, and possible health implications unique to specific populations. This review highlights existing information deficiencies and emphasises the need for comprehensive, longitudinal epidemiological and mechanistic investigations to inform regulatory decisions and public health recommendations.</p>

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Potential effects of neotame on human health: a review

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Amjad Mahmood Qadir,
  • Rebaz Anwar Omer

摘要

Artificial sweeteners have become essential in contemporary diets as alternatives to sugar to combat health issues like obesity and diabetes. Neotame, a structurally modified derivative of aspartame, has received global regulatory clearance owing to its exceptional sweetness, metabolic efficacy, and chemical stability. This paper thoroughly analyses neotame’s physicochemical characteristics, metabolic pathways, toxicological profile, and possible effects on human health. Data from animal models, in vitro experiments, and restricted human clinical investigations consistently provide a favourable safety profile, with zero bioaccumulation risk and minimal environmental persistence relative to other sweeteners. Moreover, neotame’s rapid metabolism diminishes methanol synthesis, making it suitable for individuals with phenylketonuria within prescribed consumption limits. However, concerns persist about the long-term metabolic and microbiome consequences, indirect environmental exposure, and possible health implications unique to specific populations. This review highlights existing information deficiencies and emphasises the need for comprehensive, longitudinal epidemiological and mechanistic investigations to inform regulatory decisions and public health recommendations.