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<p>Vitamin B<sub>6</sub> (pyridoxine) plays a crucial role in various metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and immune function. Conventional methods for detecting vitamin B<sub>6</sub> rely on chromatographic and enzymatic techniques, which, despite their accuracy, suffer from invasiveness and complexity. In this study, we present a novel microneedle (MN)-based electrochemical sensor utilizing methacrylated hyaluronic acid (MeHA) for the rapid and minimally invasive detection of vitamin B<sub>6</sub> in human body. The MeHA MN array (MNA) was fabricated via a UV-induced crosslinking process, allowing for rapid swelling and efficient extraction of pyridoxine. Electrochemical measurements were performed using a screen-printed electrode (SPE) to quantify pyridoxine levels. Our results demonstrated that the sensor effectively detected pyridoxine concentrations as low as 2 mM, providing a promising alternative for real-time, painless, and user-friendly vitamin B<sub>6</sub> monitoring.</p>

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Methacrylated hyaluronic acid microneedle-based electrochemical sensor for vitamin B6 monitoring

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • JaeHyoung Yun,
  • WonHyoung Ryu,
  • Junhui Park,
  • SeungHyun Park

摘要

Vitamin B6 (pyridoxine) plays a crucial role in various metabolic processes, including amino acid metabolism, neurotransmitter synthesis, and immune function. Conventional methods for detecting vitamin B6 rely on chromatographic and enzymatic techniques, which, despite their accuracy, suffer from invasiveness and complexity. In this study, we present a novel microneedle (MN)-based electrochemical sensor utilizing methacrylated hyaluronic acid (MeHA) for the rapid and minimally invasive detection of vitamin B6 in human body. The MeHA MN array (MNA) was fabricated via a UV-induced crosslinking process, allowing for rapid swelling and efficient extraction of pyridoxine. Electrochemical measurements were performed using a screen-printed electrode (SPE) to quantify pyridoxine levels. Our results demonstrated that the sensor effectively detected pyridoxine concentrations as low as 2 mM, providing a promising alternative for real-time, painless, and user-friendly vitamin B6 monitoring.