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<p>Obesity is a major modifiable risk factor for early-onset ischemic heart disease (IHD), yet its contribution to the global burden across regions and demographics is not fully quantified. This study assesses global trends in obesity-related early-onset IHD, focusing on young adults (aged 25–39 years). We utilized Global Burden of Disease Study 2021 data to track 30-year trends in obesity and early-onset IHD via average annual percentage changes (AAPCs) and socio-demographic index (SDI)-stratified disability-adjusted life year (DALY) counts. Pearson correlation was then applied to evaluate the associations between these variables. Further multi-factor adjustment analysis was conducted using a multivariable linear regression model on 5-year age-stratified data. A significant positive correlation was found between the AAPC in obesity age-standardized prevalence rate (ASPR) and the AAPC in early-onset IHD age-standardized mortality rate (ASMR) (<i>ρ</i> = 0.36, <i>P</i> &lt; 0.001) and ASPR (<i>ρ</i> = 0.29, <i>P</i> &lt; 0.001) among young males, with stronger associations than in females. The impact of obesity on early-onset IHD prevalence and mortality strengthened with age, peaking at 35–39 years old for both male and female. Even after having adjusted for dietary, environmental, and metabolic risk factors, obesity remains the top IHD risk factor in almost all subgroups. Clearly, obesity is strongly linked to higher morbidity and mortality in early-onset IHD.</p>

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Global Trends in Early-Onset Ischemic Heart Disease Linked to Obesity, 1990–2021: Insights from the Global Burden of Disease Study

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Liujia Yang,
  • Hongwei Ji,
  • Jiawen Zhang,
  • Honghao Huang,
  • Wei Xu,
  • Donghao Wang,
  • Zheng Zhang,
  • Xinyue Huang,
  • Qi Liu,
  • Yiming Zhong,
  • Yifan Chen,
  • Jun Pu

摘要

Obesity is a major modifiable risk factor for early-onset ischemic heart disease (IHD), yet its contribution to the global burden across regions and demographics is not fully quantified. This study assesses global trends in obesity-related early-onset IHD, focusing on young adults (aged 25–39 years). We utilized Global Burden of Disease Study 2021 data to track 30-year trends in obesity and early-onset IHD via average annual percentage changes (AAPCs) and socio-demographic index (SDI)-stratified disability-adjusted life year (DALY) counts. Pearson correlation was then applied to evaluate the associations between these variables. Further multi-factor adjustment analysis was conducted using a multivariable linear regression model on 5-year age-stratified data. A significant positive correlation was found between the AAPC in obesity age-standardized prevalence rate (ASPR) and the AAPC in early-onset IHD age-standardized mortality rate (ASMR) (ρ = 0.36, P < 0.001) and ASPR (ρ = 0.29, P < 0.001) among young males, with stronger associations than in females. The impact of obesity on early-onset IHD prevalence and mortality strengthened with age, peaking at 35–39 years old for both male and female. Even after having adjusted for dietary, environmental, and metabolic risk factors, obesity remains the top IHD risk factor in almost all subgroups. Clearly, obesity is strongly linked to higher morbidity and mortality in early-onset IHD.