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<p>The repair of severe bone defects remains a significant challenge in the field of orthopedics. 3D-printed metal-based scaffolds have been widely applied in bone repair due to their excellent structural and mechanical adaptability. However, conventional porous scaffolds lack the microstructure that mimics the extracellular matrix (ECM), limiting their osteointegration potential. Therefore, the development of composite bone repair materials with both biomimetic structures and biological activity has become a research focus. This study is based on the design of triply periodic minimal surfaces (TPMS) and constructs a melt-processed porous tantalum scaffold using gyroid and diamond units. Additionally, a gelatin-alginate-magnesium-lithium silicate (GE-SA-LAP) composite polymer is infiltrated into the scaffold, followed by freeze-drying to form a new composite bone scaffold material with both structural biomimicry and functionality. The TPMS structure mimics the microstructure and mechanical properties of natural trabecular bone, while the polymer filling further mimics the ECM microenvironment, optimizing conditions for cell attachment and proliferation. The characteristics and biocompatibility of the porous tantalum-polymer composite scaffold were evaluated through finite element simulation, mechanical property testing, scanning electron microscopy, and in vitro cell experiments. Finite element analysis revealed that the elastic modulus of the scaffolds in each group ranged from 1.21 to 1.55 GPa, yield strength ranged from 29.81 to 39.68 MPa, and permeability ranged from 2.72×10<sup>−8</sup> to 3.45×10<sup>−8</sup> m<sup>2</sup>, falling within the range of human cortical and trabecular bone. The GE-SA-LAP composite polymer, which fills the pores, exhibits high porosity and provides an ideal biological microenvironment for cell attachment. In vitro cell experiments further validated that the composite scaffold outperforms the pure tantalum scaffold in terms of cell attachment and proliferation, demonstrating exceptional potential for bone tissue repair.</p>

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Fabrication of Functionally Fused Porous Tantalum/Lithium Magnesium Silicate Polymer Bone Repair Scaffolds

  • 期刊论文

  • 发表日期：

    2025年7月14日

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  • Lei Jing,
  • Jizhe Hai,
  • Chunlong Shan,
  • Qingyu Xu,
  • Yueheng Lei,
  • Haijie Li

摘要

The repair of severe bone defects remains a significant challenge in the field of orthopedics. 3D-printed metal-based scaffolds have been widely applied in bone repair due to their excellent structural and mechanical adaptability. However, conventional porous scaffolds lack the microstructure that mimics the extracellular matrix (ECM), limiting their osteointegration potential. Therefore, the development of composite bone repair materials with both biomimetic structures and biological activity has become a research focus. This study is based on the design of triply periodic minimal surfaces (TPMS) and constructs a melt-processed porous tantalum scaffold using gyroid and diamond units. Additionally, a gelatin-alginate-magnesium-lithium silicate (GE-SA-LAP) composite polymer is infiltrated into the scaffold, followed by freeze-drying to form a new composite bone scaffold material with both structural biomimicry and functionality. The TPMS structure mimics the microstructure and mechanical properties of natural trabecular bone, while the polymer filling further mimics the ECM microenvironment, optimizing conditions for cell attachment and proliferation. The characteristics and biocompatibility of the porous tantalum-polymer composite scaffold were evaluated through finite element simulation, mechanical property testing, scanning electron microscopy, and in vitro cell experiments. Finite element analysis revealed that the elastic modulus of the scaffolds in each group ranged from 1.21 to 1.55 GPa, yield strength ranged from 29.81 to 39.68 MPa, and permeability ranged from 2.72×10−8 to 3.45×10−8 m2, falling within the range of human cortical and trabecular bone. The GE-SA-LAP composite polymer, which fills the pores, exhibits high porosity and provides an ideal biological microenvironment for cell attachment. In vitro cell experiments further validated that the composite scaffold outperforms the pure tantalum scaffold in terms of cell attachment and proliferation, demonstrating exceptional potential for bone tissue repair.