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<p>The T<sub>1</sub> and T<sub>2</sub> values of magnetic resonance imaging phantoms used by researchers should be equivalent to those of the target tissue. However, this is difficult to achieve because of variations in the phantoms depending on the type and concentration of contrast agents and coagulants. The aim of this study was to elucidate the utility of a determination equation derived using the relaxivity of the contrast agent and coagulant. We prepared phantoms using 0.05–10&#xa0;mmol&#xa0;L<sup>−1</sup> contrast agent (Gadovist<sup>®</sup>; Bayer Yakuhin, Ltd., Osaka, Japan) and 0.1–5.0 wt% agar (agar, powder [010-15815]; Fujifilm Wako Pure Chemical Corporation, Osaka, Japan) and measured their T<sub>1</sub> and T<sub>2</sub> values. Determination equations for T<sub>1</sub> and T<sub>2</sub> values were derived using the relaxivity calculated from the T<sub>1</sub> and T<sub>2</sub> values of the contrast agent and coagulant. Subsequently, the determined values were compared with the measured values. The error rate of the determined T<sub>1</sub> and T<sub>2</sub> values were 7.66 ± 6.60% and 5.66 ± 4.05%, respectively, with correlation coefficients of 0.996 and 0.999. These results indicate that this method enables easy and highly accurate estimation of T<sub>1</sub> and T<sub>2</sub> values in MRI phantoms.</p>

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Development of estimation method for T1 and T2 values using the relaxivity of contrast agent and coagulant for a magnetic resonance imaging phantom

  • 期刊论文

  • 发表日期：

    2025年3月23日

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  • Hiroki Okada,
  • Norikazu Koori,
  • Hatsune Shimizu,
  • Shohei Yamamoto,
  • Tetsuya Komatsuzaki,
  • Hiraku Fuse,
  • Kota Sasaki,
  • Shin Miyakawa,
  • Kenji Yasue,
  • Masato Takahashi

摘要

The T1 and T2 values of magnetic resonance imaging phantoms used by researchers should be equivalent to those of the target tissue. However, this is difficult to achieve because of variations in the phantoms depending on the type and concentration of contrast agents and coagulants. The aim of this study was to elucidate the utility of a determination equation derived using the relaxivity of the contrast agent and coagulant. We prepared phantoms using 0.05–10 mmol L−1 contrast agent (Gadovist®; Bayer Yakuhin, Ltd., Osaka, Japan) and 0.1–5.0 wt% agar (agar, powder [010-15815]; Fujifilm Wako Pure Chemical Corporation, Osaka, Japan) and measured their T1 and T2 values. Determination equations for T1 and T2 values were derived using the relaxivity calculated from the T1 and T2 values of the contrast agent and coagulant. Subsequently, the determined values were compared with the measured values. The error rate of the determined T1 and T2 values were 7.66 ± 6.60% and 5.66 ± 4.05%, respectively, with correlation coefficients of 0.996 and 0.999. These results indicate that this method enables easy and highly accurate estimation of T1 and T2 values in MRI phantoms.