The k-set tree connectivity, as a natural extension of classical connectivity, is an extremely significant index to measure the fault-tolerance of interconnection networks. For a connected graph \(G=(V, E)\) and a subset \(S\subseteq V\) , an S-tree \(T=(V',E')\) of graph G is a tree that contains the subset S. Any two S-trees T and \(T'\) are internally disjoint if and only if \(E(T)\cap E(T')=\emptyset \) and \(V(T)\cap V(T')=S\) . The cardinality of maximum internally disjoint S-trees is defined as \(\kappa _{G}(S)\) , and the k-set tree connectivity is denoted by \(\kappa _{k}(G)=\min \{\kappa _{G}(S)|S\subseteq V(G)\ \text {and} \ |S|=k\}\) . In this note, we determine the 4-set tree connectivity of \(HFQ_{n}\) . That is, \(\kappa _{4}(HFQ_{n})=n+1\) for \(n\ge 7\) , where \(HFQ_{n}\) is hierarchical folded hypercube.