Scholarlink

<p>Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system (CNS) observed in immunocompromised individuals. We retrospectively evaluated the clinical courses of PML in patients with hematological malignancies at North Japan Hematology Study Group institutions, using patients with human immunodeficiency virus (HIV) infection as a reference. Eight PML patients had hematological malignancies and 9 had HIV infection. CD4 + T cell counts were markedly low in patients with hematological malignancies (median 168/μl, range 48.4–330/μl) and did not differ significantly from those in patients with HIV infection (median 28/μl, range 8–225.4/μl). IgG levels were significantly lower in patients with hematological malignancies (median 643.5&#xa0;mg/dL, range 205–2478&#xa0;mg/dL) than in patients with with HIV infection (median 1691.5&#xa0;mg/dL, range 1304–3014&#xa0;mg/dL) (<i>p</i> &lt; 0.01). Almost all patients with hematological malignancies died after progression of PML (median time from onset to death, 136&#xa0;days). In contrast, seven patients with HIV infection were alive at the end of follow-up. The incidence of PML in patients with hematological malignancies may increase with the introduction of new antibody drugs and cellular therapies in future. Considering the poor prognosis, greater caution is warranted regarding this serious complication.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Characteristics of progressive multifocal leukoencephalopathy in hematological malignancies, With reference to HIV-infected patients

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月24日

查看全文
  • Emi Yokoyama,
  • Taisuke Harada,
  • Tomoyuki Endo,
  • Hideki Goto,
  • Junichi Sugita,
  • Masayuki Aiba,
  • Mutsumi Takahata,
  • Takuto Miyagishima,
  • Hajime Senjo,
  • Satoshi Iyama,
  • Shuichiro Takahashi,
  • Masayo Yamamoto,
  • Motohiro Shindo,
  • Kazuya Sato,
  • Junichi Hashiguchi,
  • Tatsuo Oyake,
  • Takanori Teshima

摘要

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the central nervous system (CNS) observed in immunocompromised individuals. We retrospectively evaluated the clinical courses of PML in patients with hematological malignancies at North Japan Hematology Study Group institutions, using patients with human immunodeficiency virus (HIV) infection as a reference. Eight PML patients had hematological malignancies and 9 had HIV infection. CD4 + T cell counts were markedly low in patients with hematological malignancies (median 168/μl, range 48.4–330/μl) and did not differ significantly from those in patients with HIV infection (median 28/μl, range 8–225.4/μl). IgG levels were significantly lower in patients with hematological malignancies (median 643.5 mg/dL, range 205–2478 mg/dL) than in patients with with HIV infection (median 1691.5 mg/dL, range 1304–3014 mg/dL) (p < 0.01). Almost all patients with hematological malignancies died after progression of PML (median time from onset to death, 136 days). In contrast, seven patients with HIV infection were alive at the end of follow-up. The incidence of PML in patients with hematological malignancies may increase with the introduction of new antibody drugs and cellular therapies in future. Considering the poor prognosis, greater caution is warranted regarding this serious complication.