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<p>Tumor-associated bronchiolitis obliterans (BO) is a major cause of death and is frequently complicated by paraneoplastic pemphigoid (PNP). In this study, three cases of follicular lymphoma (FL) with BO were retrospectively analyzed. All cases were complicated by PNP. All patients achieved a tumor response with anti-CD20 monoclonal antibody-containing treatment, and two patients showed clinical improvement in PNP. However, BO continued to progress, and two of the three patients developed pulmonary infections.</p>

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Bronchiolitis obliterans complicating follicular lymphoma: a case series and clinical insights

  • 期刊论文

  • 发表日期：

    2026年2月3日

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  • Takashi Nakamura,
  • Kazuhito Suzuki,
  • Masaharu Kawashima,
  • Takeshi Saito,
  • Hiroki Yokoyama,
  • Atsushi Katsube,
  • Ryoko Fukushima,
  • Hiroto Ishii,
  • Sayaka Oshima,
  • Susumu Tanoue,
  • Yo Sakayori,
  • Iku Kamitani,
  • Keitaro Okuda,
  • Takanori Numata,
  • Jun Araya,
  • Shingo Yano

摘要

Tumor-associated bronchiolitis obliterans (BO) is a major cause of death and is frequently complicated by paraneoplastic pemphigoid (PNP). In this study, three cases of follicular lymphoma (FL) with BO were retrospectively analyzed. All cases were complicated by PNP. All patients achieved a tumor response with anti-CD20 monoclonal antibody-containing treatment, and two patients showed clinical improvement in PNP. However, BO continued to progress, and two of the three patients developed pulmonary infections.